Discovery and replication of cerebral blood flow differences in major depressive disorder.

Molecular Psychiatry
Crystal M CooperMadhukar H Trivedi

Abstract

Major depressive disorder (MDD) is a serious, heterogeneous disorder accompanied by brain-related changes, many of which are still to be discovered or refined. Arterial spin labeling (ASL) is a neuroimaging technique used to measure cerebral blood flow (CBF; perfusion) to understand brain function and detect differences among groups. CBF differences have been detected in MDD, and may reveal biosignatures of disease-state. The current work aimed to discover and replicate differences in CBF between MDD participants and healthy controls (HC) as part of the EMBARC study. Participants underwent neuroimaging at baseline, prior to starting study medication, to investigate biosignatures in MDD. Relative CBF (rCBF) was calculated and compared between 106 MDD and 36 HC EMBARC participants (whole-brain Discovery); and 58 MDD EMBARC participants and 58 HC from the DLBS study (region-of-interest Replication). Both analyses revealed reduced rCBF in the right parahippocampus, thalamus, fusiform and middle temporal gyri, as well as the left and right insula, for those with MDD relative to HC. Both samples also revealed increased rCBF in MDD relative to HC in both the left and right inferior parietal lobule, including the supramarginal and angu...Continue Reading

References

Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Sep 3, 2008·Archives of General Psychiatry·Edwin J C G van den OordDan Rujescu
Jun 6, 2009·Current Opinion in Neurology·Danielle S Bassett, Edward T Bullmore
Apr 29, 2010·Magnetic Resonance Imaging·Sina Aslan, Hanzhang Lu
May 25, 2010·Trends in Cognitive Sciences·Steven L Bressler, Vinod Menon
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jul 7, 2011·Nature Reviews. Neuroscience·Seth G DisnerAaron T Beck
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Sep 20, 2011·Acta Psychiatrica Scandinavica·Hanna JärnumElna-Marie Larsson
Apr 23, 2013·Biological Psychiatry·Manpreet K SinghIan H Gotlib
Jun 14, 2013·JAMA Psychiatry·Callie L McGrathHelen S Mayberg
Aug 24, 2013·The British Journal of Psychiatry : the Journal of Mental Science·J R C AlmeidaM L Phillips
Feb 8, 2014·Annals of the New York Academy of Sciences·Jessica R Andrews-HannaR Nathan Spreng
Apr 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David C AlsopGreg Zaharchuk
Jul 25, 2014·Brain : a Journal of Neurology·Nicolas A CrossleyEdward T Bullmore
Feb 24, 2015·Nature Reviews. Neuroscience·Alex FornitoMichael Breakspear
Apr 4, 2016·Journal of Psychiatric Research·Madhukar H TrivediMyrna M Weissman
Aug 5, 2016·Human Brain Mapping·D VatanseverE A Stamatakis

❮ Previous
Next ❯

Software Mentioned

SR Quick
MarsBar
SPSS
Matlab
EMBARC
SPM8
QIDS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.