Apr 8, 2016

Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans

BioRxiv : the Preprint Server for Biology
Robert J LuallenEmily R Troemel

Abstract

Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode Caenorhabditis elegans that has a unique tissue tropism compared to other parasites of C. elegans . We characterize the life cycle of this new species, Nematocida displodere , including pathogen entry, intracellular replication, and exit. N. displodere can invade multiple host tissues, including the epidermis, muscle, neurons, and intestine of C. elegans . Despite robust invasion of the intestine very little replication occurs there, with the majority of replication occurring in the muscle and epidermis. This feature distinguishes N. displodere from two closely related microsporidian pathogens, N. parisii and N. sp. 1, which exclusively invade and replicate in the intestine. Comparison of the N. displodere genome with N. parisii and N. sp. 1 reveals that N. displodere is the earliest diverging species of the Nematocida genus and devotes over 10% of its genome to a single species-specific gene family that may be me...Continue Reading

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Mentioned in this Paper

Calcinus elegans
Microorganism
Cyartonema elegans
Coleonyx elegans
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
Cardioglossa elegans
Cymbella elegans
Cyrenella elegans

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