PMID: 11310613Apr 20, 2001Paper

Discovery of a novel lead structure for anti-malarials

Bioorganic & Medicinal Chemistry
Jochen WiesnerMartin Schlitzer

Abstract

From a library of 61 compounds available from former studies 2,5-bis-acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials.

Citations

Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·J WiesnerM Schlitzer
Sep 15, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Renata GrzywaMarcin Sieńczyk
Jul 14, 2006·Bioorganic & Medicinal Chemistry·Aihua XieRobert J Doerksen
Apr 24, 2003·Medicinal Research Reviews·Mei-Lin Go
May 16, 2006·Medicinal Research Reviews·Suryanaryana VangapanduRahul Jain
Aug 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maureen GumboSetshaba D Khanye

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