Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

doi:10.1016/j.bmcl.2004.11.001

PMID: 15603933DOI: 10.1016/j.bmcl.2004.11.001Dec 18, 2004

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

Bioorganic & Medicinal Chemistry Letters

Yutaka NakajimaMasayuki Kato

Abstract

The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.

References

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Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs

May 10, 1984·Nature·J R ArchS Wilson

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

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Citations

Comparative 3D QSAR study on β(1)-, β(2)-, and β(3)-adrenoceptor agonists.

Dec 21, 2010·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·P Senthil Kumar, Prasad V Bharatam

Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation

Sep 3, 2008·The Journal of Organic Chemistry·W C Peter TsangStephen L Buchwald

Isolation of a Bacillus strain producing ketone reductase with high substrate tolerance

Sep 22, 2009·Bioresource Technology·Yan XieYi Xu

β(3)-Adrenoceptor ligand development history through patent review

Mar 18, 2011·Expert Opinion on Therapeutic Patents·Maria Grazia Perrone, Antonio Scilimati

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Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

Abstract

References

Molecular characterization of the human beta 3-adrenergic receptor

Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

Citations

Comparative 3D QSAR study on β(1)-, β(2)-, and β(3)-adrenoceptor agonists.

Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation

Isolation of a Bacillus strain producing ketone reductase with high substrate tolerance

β(3)-Adrenoceptor ligand development history through patent review

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

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