Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

Bioorganic & Medicinal Chemistry Letters
Yutaka NakajimaMasayuki Kato

Abstract

The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.

Citations

Dec 21, 2010·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·P Senthil Kumar, Prasad V Bharatam
Sep 3, 2008·The Journal of Organic Chemistry·W C Peter TsangStephen L Buchwald
Mar 18, 2011·Expert Opinion on Therapeutic Patents·Maria Grazia Perrone, Antonio Scilimati

Related Concepts

Adrenergic beta-Agonists
Cricetus
Structure-Activity Relationship
Chinese Hamster Ovary Cell
Adrenergic beta-3 Receptor Agonists

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