Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.

Bioorganic & Medicinal Chemistry Letters
Yuli XieDonald W Landry

Abstract

We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.

References

Feb 10, 2007·Nature Reviews. Drug Discovery·Philip J Hajduk, Jonathan Greer

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Citations

Feb 24, 2011·Journal of Medicinal Chemistry·Stephanie M StanfordNunzio Bottini
Nov 6, 2009·Journal of Medicinal Chemistry·Mark R KarverAmy M Barrios
Mar 1, 2012·Organic and Medicinal Chemistry Letters·Deepak K AnejaOm Prakash
Aug 28, 2014·Future Medicinal Chemistry·Jayme L Dahlin, Michael A Walters
Mar 6, 2010·Seminars in Immunopathology·Stephanie M StanfordNunzio Bottini
Jan 10, 2014·ChemMedChem·Vanessa F AhmedAmy M Barrios
Sep 27, 2018·Expert Opinion on Therapeutic Targets·F David Carmona, Javier Martín
Jul 23, 2013·ChemMedChem·Rhushikesh A KulkarniAmy M Barrios
May 21, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Shahira K AnisAliaa A Ali
Aug 21, 2013·Chembiochem : a European Journal of Chemical Biology·Rhushikesh A KulkarniAmy M Barrios
Jul 9, 2008·Journal of Medicinal Chemistry·Divya KrishnamurthyAmy M Barrios
Jul 22, 2018·Journal of Medicinal Chemistry·María Dolores Moya-GarzónMónica Díaz-Gavilán

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