Discovery of a potent anti-yeast triterpenoid saponin, clematoside-S from Urena lobata L

International Journal of Molecular Sciences
Xiao-Ling GaoZheng-Jun Xu

Abstract

Urena lobata has been used as a traditional medicinal plant in India and China. In this study, we investigated the antimicrobial activity and isolated the active compound from the leaves of U. lobata. The 80% ethanol extract from U. lobata leaves showed an effective anti-yeast activity against Saccharomyces cerevisiae (S. cerevisiae) strains. Using a combination of chromatographic methods, (-)-trachelogenin (1) and clematoside-S (2) were isolated from this plant for the first time, and their chemical structure was identified by mass spectrometry (MS) and extensive nuclear magnetic resonance (NMR) data analysis. In addition, 1 was found to be inactive against all of the test microorganisms in the antimicrobial assay, whereas 2 exhibits a specific anti-yeast activity against S. cerevisiae strains with diameter of inhibition zones in the range from 11 to 20 mm. Furthermore, the MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values of 2 against S. cerevisiae strains were detected to be in the ranges of 0.61 to 9.8 μg/mL and 2.42 to 9.8 μg/mL, respectively. This is the first report of 2 with a specific anti-yeast activity. The above result suggests the potential application of U. lobata to be use...Continue Reading

References

Aug 1, 1984·Planta medica·K MizutaniO Tanaka
Jul 31, 1998·Journal of Ethnopharmacology·B de las HerasX Chiriboga
Dec 4, 2001·Fitoterapia·U K MazumderS Bhattacharya
Jul 13, 2004·International Journal of Food Microbiology·Sara Burt
Feb 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P A Meléndez, V A Capriles
May 16, 2006·Fitoterapia·Carlo F MorelliSultana Rajia
Mar 10, 2009·International Journal of Food Microbiology·Marta GorettiPietro Buzzini
May 12, 2009·Journal of Asian Natural Products Research·Li-Hua YanYu-Lin Feng
Oct 30, 2009·Phytochemistry·Anne-Claire Mitaine-OfferMarie-Aleth Lacaille-Dubois
Dec 3, 2009·Chemical & Pharmaceutical Bulletin·Akihito YokosukaYoshihiro Mimaki
Nov 10, 2010·Journal of Asian Natural Products Research·Lu JiaDe-Yun Kong
Dec 7, 2010·International Journal of Food Microbiology·Rentsenkhand TserennadmidJudit Krisch
Mar 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wei-Cai ZengQun Sun
May 1, 2010·Environmental Toxicology and Pharmacology·C A PiemeM Costache
Dec 4, 2012·Food Chemistry·Amit Kumar TyagiMaria Elisabetta Guerzoni
Oct 9, 2013·Journal of Agricultural and Food Chemistry·Sylwia PawelecAnna Stochmal

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Citations

Jun 15, 2016·Journal of Food Protection·Judit KrischCsaba Vágvölgyi
Aug 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan LuoShepo Shi
Apr 28, 2020·Phytochemistry·Nesma M MohamedSamir A Ross

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Methods Mentioned

BETA
gel column chromatography
2D-NMR
NMR

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