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Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

Scientific Reports

Nov 14, 2019

Eshan KhanAmit Kumar

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Abstract

CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington's disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these diseases share the common cause, i.e., expansion of CAG repeats. The sh...read more

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Appendicitis
Cell Growth
Crohn Disease
Huntington Disease
Nerve Degeneration
RNA
Chorionic alpha(2)-microglobulin
Poly(A)-Binding Proteins
Chemicals
Lead compound
7
1
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Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

Scientific Reports

Nov 14, 2019

Eshan KhanAmit Kumar

PMID: 31728006

DOI: 10.1038/s41598-019-53410-z

Abstract

CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington's disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these diseases share the common cause, i.e., expansion of CAG repeats. The sh...read more

Mentioned in this Paper

Appendicitis
Cell Growth
Crohn Disease
Huntington Disease
Nerve Degeneration
7
1

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