Discovery of active components in herbs using chromatographic separation coupled with online bioassay

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Li De-QiangLi Shao-Ping

Abstract

Discovery of bioactive compounds from complex mixtures is a challenge. In past decades, several strategies were developed and implemented for rapid and effective screening and characterization of bioactive components in complex matrices. This review mainly focused on the online strategies, which integrated the separation science, mass spectrometry, and bioactivity screening in a single platform, allowing simultaneous screening and characterization of active compounds from complex matrices, especially from the herbs. The online screening methodologies, including pre-column affinity-based screening and post-column bioassay, were discussed and their applied examples were also presented to illustrate the strengths and limitations of these approaches.

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Citations

Dec 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fen WeiSicen Wang
May 31, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhi-Tong ZhangDan Tang
Aug 30, 2021·Journal of Pharmaceutical and Biomedical Analysis·Yan CaoYuelin Song
Sep 29, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Xiao-Wei ZhangDe-Qiang Li

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