Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds

Bioorganic & Medicinal Chemistry Letters
P DucrayRonald Kaminsky

Abstract

A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.

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Citations

Nov 28, 2012·Analytical and Bioanalytical Chemistry·Lucie StuchlíkováLenka Skálová
May 15, 2013·Veterinary Parasitology·Ronald KaminskyHeinz Sager
Jun 23, 2011·PLoS Neglected Tropical Diseases·Piero OlliaroJennifer Keiser
Oct 28, 2008·International Journal for Parasitology·Ronald KaminskyBarry Hosking
Jul 21, 2009·Journal of Veterinary Pharmacology and Therapeutics·D KaradzovskaJ M Giraudel
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Paul McVeighAaron G Maule
Oct 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Jeannine HessGilles Gasser
Sep 10, 2014·Parasitology·L LecováL Skálová
Jan 22, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Nikhil D Amnerkar, Kishore P Bhusari
Aug 28, 2019·Scientific Reports·Mostafa A ElfawalRaffi V Aroian
Apr 30, 2015·Drug Testing and Analysis·Lucie StuchlíkováLenka Skálová
Jul 15, 2009·The Veterinary Record·B C Hosking, P A Stein
Feb 9, 2018·Acta veterinaria·Melanie AbongwaAlan P Robertson

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