PMID: 7540850Apr 1, 1995Paper

Discovery of aquaporins: a breakthrough in research on renal water transport

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
A F van LieburgP M Deen

Abstract

Several membranes of the kidney are highly water permeable, thereby enabling this organ to retain large quantities of water. Recently, the molecular identification of water channels responsible for this high water permeability has finally been accomplished. At present, four distinct renal water channels have been identified, all members of the family of major intrinsic proteins. Aquaporin 1 (AQP1), aquaporin 2 (AQP2) and the mercury-insensitive water channel (MIWC) are water-selective channel proteins, whereas the fourth, referred to as aquaporin 3 (AQP3), permits transport of urea and glycerol as well. Furthermore, a putative renal water channel (WCH3) has been found. AQP1 is expressed in apical and basolateral membranes of proximal tubules and descending limbs of Henle, AQP2 predominantly in apical membranes of principal and inner medullary collecting duct cells and AQP3 in basolateral membranes of kidney collecting duct cells. MIWC is expressed in the inner medulla of the kidney and has been suggested to be localised in the vasa recta. The human genes encoding AQP1 and AQP2 have been cloned, permitting deduction of their amino acid sequence, prediction of their two-dimensional structure by hydropathy analysis, speculations o...Continue Reading

References

May 15, 1992·Biochemical and Biophysical Research Communications·A N Van HoekJ A Dempster
Jan 1, 1991·American Journal of Medical Genetics·J M LangleyJ T Clarke
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G M Preston, P Agre
Oct 1, 1991·Pflügers Archiv : European journal of physiology·J A DempsterC H van Os
Mar 1, 1991·European Journal of Pediatrics·N Knoers, L A Monnens
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J FischbargO M Rosen
Nov 1, 1989·The American Journal of Physiology·A S Verkman
Jul 1, 1988·The Journal of Clinical Endocrinology and Metabolism·B BrennerZ Hochberg
Jan 1, 1987·The Journal of Membrane Biology·K Strange, K R Spring
Mar 1, 1984·The American Journal of Physiology·R I Macey
Jan 1, 1981·Annals of the New York Academy of Sciences·J B WadeS A Lewis
Dec 15, 1993·Biochemical and Biophysical Research Communications·T MaA S Verkman
Mar 1, 1994·The Journal of Clinical Investigation·S SasakiK Nakajima
Sep 1, 1994·The Journal of Clinical Investigation·B L SmithP Agre
Jan 1, 1994·Annual Review of Physiology·M D Breyer, Y Ando
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S NielsenH W Harris

❮ Previous
Next ❯

Citations

Sep 16, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iris BöseltAngela Schulz
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·E M Wintour
Jul 27, 2000·Molecular and Cellular Biology·H T HoS S Chung
Oct 15, 1998·Archives of Disease in Childhood·P H Baylis, T Cheetham
May 20, 1999·Archives of Disease in Childhood·V KirchlechnerF Waldhauser
Jun 24, 2006·Biochemical and Biophysical Research Communications·William K F TseChris K C Wong
Oct 21, 2016·American Journal of Physiology. Renal Physiology·Fahmy A MamuyaHua Ann Jenny Lu
Apr 16, 1998·The Journal of Biological Chemistry·Z HanR V Patil
Aug 15, 2001·American Journal of Physiology. Renal Physiology·R K Wetzel, K J Sweadner
May 1, 2020·Frontiers in Cell and Developmental Biology·Juan Pablo RigalliJoost G J Hoenderop
Jun 1, 1997·Equine Veterinary Journal. Supplement·E M Wintour, K M Moritz
May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lidija Milković, Ana Čipak Gašparović

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.