Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries

Drug Discovery Today
Xueshun WangPeng Zhan

Abstract

The rapid assembly and in situ screening of focused combinatorial fragment libraries using CuAAC click chemistry is a highly robust and efficient strategy for establishing SAR and for discovering bioactive molecules. This review outlines the current status of this methodology in drug discovery application. The inherent limitations, challenges and prospects are critically discussed.

References

Aug 9, 2003·Journal of the American Chemical Society·Lac V LeeChi-Huey Wong
Nov 13, 2003·Chembiochem : a European Journal of Chemical Biology·Ashraf BrikChi-Huey Wong
Dec 18, 2003·Drug Discovery Today·Hartmuth C Kolb, K Barry Sharpless
Feb 11, 2005·Chemical Reviews·Eric D Brown, Gerard D Wright
Jun 4, 2005·Chembiochem : a European Journal of Chemical Biology·Ashraf BrikChi-Huey Wong
Nov 9, 2005·Bioorganic & Medicinal Chemistry·Fu-Sen LiangChi-Huey Wong
Apr 11, 2006·Organic & Biomolecular Chemistry·Ashraf BrikChi-Huey Wong
Jul 25, 2006·Journal of Chemical Information and Modeling·Gerald M Maggiora
Aug 11, 2006·Organic Letters·Jun WangShao Q Yao
Aug 28, 2007·Chemical Society Reviews·Yu L Angell, Kevin Burgess
Nov 17, 2007·Nature Protocols·Rajavel SrinivasanShao Q Yao
Feb 23, 2008·Organic & Biomolecular Chemistry·Su Ling NgShao Q Yao
Mar 6, 2008·Journal of Medicinal Chemistry·Sanjeev KumarAlexander J Muller
Mar 12, 2008·Current Opinion in Chemical Biology·Valerie J Gillet
May 7, 2008·Organic Letters·Rajavel SrinivasanShao Q Yao
Aug 14, 2008·Chemical Reviews·Morten Meldal, Christian Wenzel Tornøe
Mar 26, 2009·Accounts of Chemical Research·William L Jorgensen
Jul 11, 2009·Organic & Biomolecular Chemistry·Rajavel SrinivasanShao Q Yao
Jul 16, 2009·Mini Reviews in Medicinal Chemistry·Peng ZhanErik De Clercq
Sep 15, 2009·Current Medicinal Chemistry·Peng ZhanErik De Clercq
Sep 25, 2009·Current Opinion in Pharmacology·Lorenz M Mayr, Dejan Bojanic
Dec 8, 2009·Journal of Medicinal Chemistry·Giampiero ColombanoArmando A Genazzani
Dec 22, 2009·Organic & Biomolecular Chemistry·Karunakaran A KaleshShao Q Yao
Jan 13, 2010·Organic & Biomolecular Chemistry·Tracey M Gloster, Gideon J Davies
Feb 19, 2010·Angewandte Chemie·Charles E Hoyle, Christopher N Bowman
May 8, 2010·Organic & Biomolecular Chemistry·Karunakaran A KaleshShao Q Yao
Jun 24, 2010·Bioorganic & Medicinal Chemistry Letters·Jieun Yoon, Jae-Sang Ryu
Nov 30, 2010·Current Medicinal Chemistry·Peng ZhanErik De Clercq
May 31, 2011·Bioorganic & Medicinal Chemistry Letters·Christopher J MonceauxPaul R Carlier
Jun 29, 2011·Angewandte Chemie·Eelco RuijterRomano V A Orru
Sep 29, 2011·Chemistry, an Asian Journal·Sandip G AgalaveVandana S Pore
Nov 23, 2011·Bioorganic & Medicinal Chemistry Letters·Takayuki IrieMasaaki Sawa
Jan 28, 2012·Journal of Medicinal Chemistry·Matthias G J BaudMatthew J Fuchter
May 24, 2012·Journal of Medicinal Chemistry·Ute F RöhrigOlivier Michielin
Jun 16, 2012·Biochemistry·Duncan E ScottChris Abell

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Citations

Jun 16, 2016·The Journal of Organic Chemistry·Eva Pušavec KirarJurij Svete
Dec 6, 2016·Angewandte Chemie·Bo PengShao Q Yao
Dec 9, 2016·Chemical Communications : Chem Comm·Karen WrightFrançois Couty
Nov 1, 2018·Organic & Biomolecular Chemistry·Silvia Roscales, Joaquín Plumet
Dec 13, 2018·Chemical Communications : Chem Comm·Antoine BlancDavid M Perrin
Aug 17, 2019·Expert Opinion on Drug Discovery·Rafael Ferreira DantasFloriano Paes Silva-Junior
Aug 21, 2019·Chemistry : a European Journal·Oleksandr O GrygorenkoDuncan B Judd
Apr 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Firdaus Rahaman GayenBiswajit Saha
Jun 3, 2020·Future Medicinal Chemistry·Shujing XuPeng Zhan
Mar 3, 2017·Journal of Asian Natural Products Research·Xiao-Xi LvZhuo-Wei Hu
Sep 23, 2020·Archiv der Pharmazie·Lian-Shun FengDuan Liu
Aug 15, 2020·Chemistry, an Asian Journal·Upma GulatiJoydev K Laha
May 4, 2017·Chemical Communications : Chem Comm·Fangyu FuDidier Astruc
Jun 2, 2017·Chemical Science·Assunta MarrocchiLuigi Vaccaro
Sep 27, 2019·International Journal of Molecular Sciences·Anja HarejSilvana Raić-Malić
May 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yingchun XiaYanbing Lu
May 17, 2019·Expert Opinion on Drug Discovery·Xiangyi JiangPeng Zhan
Jan 7, 2021·Chemical Communications : Chem Comm·Troy A BemisMichael D Burkart
Jul 1, 2020·European Journal of Medicinal Chemistry·Yucen TaoPeng Zhan
Mar 13, 2021·Advanced Functional Materials·Hector D NeiraAmy E Herr
May 25, 2021·Bioorganic & Medicinal Chemistry·Elena LenciAndrea Trabocchi
Oct 13, 2020·Chemical Reviews·Patrick R Fitzgerald, Brian M Paegel
Jun 16, 2021·Bioorganic & Medicinal Chemistry·Zuzanna MolędaJan K Maurin
May 6, 2019·Journal of Medicinal Chemistry·Gaochan WuPeng Zhan
Jun 17, 2020·Journal of the American Chemical Society·Sung-Eun SuhShannon S Stahl

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