Discovery of centrosomal RNA and centrosomal hypothesis of cellular ageing and differentiation

Nucleosides, Nucleotides & Nucleic Acids
Konstantin ChichinadzeA Lazarashvili

Abstract

In 2006, a group of scientists studying centrosomes of Spisula solidissima mollusc oocytes under the leadership of Alliegro (Alliegro, M.C.; Alliegro, M.A.; Palazzo, R.E. Centrosome-associated RNA in surf clam oocytes. Proc. Natl. Acad. Sci. USA 2006, 103(24), 9034-9038) reliably demonstrated the existence of specific RNA in centrosome, called centrosomal RNA (cnRNA). In their first article, five different RNAs (cnRNAs 11, 102, 113, 170, and 184) were described. During the process of full sequencing of the first transcript (cnRNA 11), it was discovered that the transcript contained a conserved structure-a reverse transcriptase domain located together with the most important centrosomal protein, γ-tubulin. In an article published in 2005, we made assumptions about several possible mechanisms for determining the most important functions of centrosomal structures and referred to one of them as a "RNA-dependent mechanism." This idea about participation of hypothetic centrosomal small interference RNA and/or microRNA in the process was made one year prior to the discovery of cnRNA by Alliegro's group. The discovery of specific RNA in a centrosome is indirect evidence of a centrosomal hypothesis of cellular ageing and differentiation...Continue Reading

References

Mar 1, 1977·Cell·S R HeidemannM W Kirschner
Feb 1, 1990·The Journal of Cell Biology·C KlotzE Karsenti
Jan 1, 1987·International Review of Cytology·I A Vorobjev, E S Nadezhdina
Oct 1, 1995·Current Opinion in Cell Biology·C D RoskelleyM J Bissell
Jan 19, 1999·Methods in Cell Biology·R E Palazzo, J M Vogel
Dec 28, 2000·The Quarterly Review of Biology·M J ChapmanL Margulis
Feb 17, 2001·Trends in Ecology & Evolution·M -A. SelosseB Godelle
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·R P Jansen
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I M Palacios, D St Johnston
Mar 23, 2002·Cell·Malgorzata KlocLaurence D Etkin
Oct 3, 2002·The Journal of Cell Biology·Alexey KhodjakovChuo-Lung Wang
Oct 3, 2002·Nature Reviews. Genetics·Michael T McManus, Phillip A Sharp
Nov 26, 2002·Trends in Genetics : TIG·Hildegard Tekotte, Ilan Davis
Jan 9, 2003·Current Opinion in Cell Biology·Janine Beisson, Michel Wright
Aug 19, 2003·Developmental Biology·Maria Giovanna Riparbelli, Giuliano Callaini
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Mar 24, 2004·Current Opinion in Cell Biology·Miguel López de Heredia, Ralf-Peter Jansen
May 15, 2004·Nature Reviews. Genetics·David P Bartel, Chang-Zheng Chen
Jun 8, 2004·Traffic·Sandrine Etienne-Manneville
Sep 4, 2004·Genome Biology·Eric A MiskaH Robert Horvitz
Sep 24, 2004·Current Biology : CB·Sharat Gadde, Rebecca Heald
Sep 24, 2004·Biology of Reproduction·Gaurishankar ManandharPeter Sutovsky
Jan 18, 2005·Journal of Cell Science·Malgorzata Kloc, Laurence D Etkin
Mar 2, 2005·The Journal of Cell Biology·Sabrina La TerraAlexey Khodjakov
May 12, 2005·Cell Biology International·J Tkemaladze, K Chichinadze
Jun 2, 2005·The Journal of Cell Biology·Lynne M Quarmby, Jeremy D K Parker
Jun 16, 2005·Nature Reviews. Molecular Cell Biology·Valentina Perissi, Michael G Rosenfeld
Aug 3, 2005·Nature Reviews. Molecular Cell Biology·Campbell W Gourlay, Kathryn R Ayscough
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Stephen DoxseyWilliam Theurkauf
Dec 6, 2005·Journal of Cellular Biochemistry·Richard C Scarpulla
Dec 13, 2005·Biochemistry. Biokhimii︠a︡·J V Tkemaladze, K N Chichinadze
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark C AlliegroRobert E Palazzo
Jul 4, 2006·Cell·Jose L Badano, Nicholas Katsanis
Jul 4, 2006·Cell·Renata BastoJordan W Raff
Jul 6, 2006·Nature Cell Biology·Thoru Pederson
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lynn MargulisJohn Hall
Aug 4, 2007·Journal of Cellular Physiology·Chia-Ying Chu, Tariq M Rana
Nov 3, 2007·Evolution & Development·Evan P KingsleyJ David Lambert
Jan 2, 2008·The Journal of Cell Biology·Michael D BlowerRebecca Heald

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