Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro.

Antiviral Research
Ruikun DuQinghua Cui


The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease. Here we examined the inhibitory abilities of two broad-spectrum antiviral natural products chebulagic acid (CHLA) and punicalagin (PUG) against SARS-CoV-2 viral replication. Both CHLA and PUG reduced virus-induced plaque formation in Vero-E6 monolayer at noncytotoxic concentrations, by targeting the enzymatic activity of viral 3-chymotrypsin-like cysteine protease (3CLpro) as allosteric regulators. Our study demonstrates the potential use of CHLA and PUG as novel COVID-19 therapies.


Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kiira RatiaAndrew D Mesecar
Apr 24, 2020·New Microbes and New Infections·Saima HamidGulab Khan Rohela
May 21, 2020·Emerging Microbes & Infections·Ya-Nan ZhangBo Zhang
May 24, 2020·The New England Journal of Medicine·John H BeigelUNKNOWN ACTT-1 Study Group Members
Sep 25, 2020·Cell·Thomas Mandel ClausenJeffrey D Esko
Oct 5, 2020·Signal Transduction and Targeted Therapy·Zhe-Rui ZhangBo Zhang
Oct 9, 2020·Nature Communications·Alice DouangamathMartin A Walsh

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