Discovery of genes implicated in placode formation

Developmental Biology
Kathryn L McCabeMarianne Bronner-Fraser

Abstract

The peripheral nervous system of the head is derived from cranial ectodermal placodes and neural crest cells. Placodes arise from thickenings in the cranial ectoderm that invaginate or ingress to form sensory ganglia and the paired sense organs. We have combined embryological techniques with array technology to identify genes that are expressed as a consequence of placode induction. As a secondary screen, we used whole mount in situ hybridization to determine the expression of candidate genes in various placodal domains. The results reveal 52 genes that are found in one or more placodes, including the olfactory, trigeminal, and otic placodes. Expression of some of these genes is retained in placodal derivatives. Furthermore, several genes are common to both neural crest and ectodermal placodes. This study presents the first array of candidate genes implicated in placode development, providing numerous new molecular markers for various stages of placode formation. Importantly, the results uncover previously unknown commonalities in genes expressed by multiple placodes and shared properties between placodes and other migratory cells, like neural crest cells.

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Citations

Mar 7, 2009·The Journal of Comparative Neurology·Kathryn L McCabeMarianne Bronner-Fraser
Jan 22, 2011·Journal of Neurochemistry·Kathryn L McCabe, Marianne Bronner
May 9, 2006·Developmental Biology·Gerhard Schlosser
Oct 26, 2007·Developmental Biology·Matthew J Kourakis, William C Smith
Jun 9, 2009·Developmental Biology·Kathryn L McCabe, Marianne Bronner-Fraser
May 12, 2006·Journal of Neurobiology·Raymond RomandEri Hashino
Sep 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kathryn L McCabeMarianne Bronner-Fraser
Jun 7, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gerhard Schlosser
Apr 9, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bruce B Riley
Feb 12, 2005·Development·Jill A HelmsMinal D Tapadia
Mar 17, 2021·Disease Models & Mechanisms·Beverly A KarpinskiAnthony-Samuel LaMantia
Aug 12, 2021·Disease Models & Mechanisms·Beverly A KarpinskiAnthony-Samuel LaMantia
Apr 18, 2008·Development·Kathryn L McCabe, Marianne Bronner-Fraser

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