PMID: 8942957Nov 26, 1996Paper

Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives

Proceedings of the National Academy of Sciences of the United States of America
T Tully

Abstract

The biological bases of learning and memory are being revealed today with a wide array of molecular approaches, most of which entail the analysis of dysfunction produced by gene disruptions. This perspective derives both from early "genetic dissections" of learning in mutant Drosophila by Seymour Benzer and colleagues and from earlier behavior-genetic analyses of learning and in Diptera by Jerry Hirsh and coworkers. Three quantitative-genetic insights derived from these latter studies serve as guiding principles for the former. First, interacting polygenes underlie complex traits. Consequently, learning/memory defects associated with single-gene mutants can be quantified accurately only in equilibrated, heterogeneous genetic backgrounds. Second, complex behavioral responses will be composed of genetically distinct functional components. Thus, genetic dissection of complex traits into specific biobehavioral properties is likely. Finally, disruptions of genes involved with learning/memory are likely to have pleiotropic effects. As a result, task-relevant sensorimotor responses required for normal learning must be assessed carefully to interpret performance in learning/memory experiments. In addition, more specific conclusions wil...Continue Reading

References

Jan 18, 1979·Nature·W G QuinnR Booker
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T R McGuire, J Hirsch
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y DudaiS Benzer
Jun 1, 1992·Journal of Comparative Psychology·K L LofdahlJ Hirsch
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C N ChenR L Davis
Sep 1, 1985·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·T Tully, W G Quinn
Dec 1, 1973·Scientific American·S Benzer
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S T JacobE S Vessel
Dec 1, 1971·Journal of Comparative and Physiological Psychology·M C Nelson
Sep 1, 1984·Behavior Genetics·T Tully
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R Booker, W G Quinn
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J S Duerr, W G Quinn
May 1, 1995·Trends in Neurosciences·J DeZazzo, T Tully
Oct 7, 1994·Cell·T TullyM Del Vecchio
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E FolkersW G Quinn
Apr 1, 1996·Current Opinion in Neurobiology·J C Yin, T Tully
Dec 1, 1958·Journal of Comparative and Physiological Psychology·J HIRSCH, J C BOUDREAU
Nov 1, 1960·Psychological Bulletin·M R ROSENZWEIGE L BENNETT
Dec 13, 1963·Science·J HIRSCH

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Citations

Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E B Keverne
Dec 18, 2002·Journal of Neurobiology·Oliver Hobert
May 29, 2003·Journal of Insect Physiology·A B. Barron
Oct 15, 2003·Behavioural Processes·Bruno van Swinderen, Rozi Andretic
Feb 18, 1998·Current Opinion in Neurobiology·R J Greenspan
Mar 12, 2005·Nature Reviews. Genetics·Gene E RobinsonCharles W Whitfield
Mar 11, 2000·The American Journal of Clinical Hypnosis·E L Rossi
Feb 6, 2008·Zebrafish·D WrightJ Krause
Sep 18, 2009·Proceedings. Biological Sciences·Sachin Sarin, Reuven Dukas
Feb 24, 2000·Archives of Disease in Childhood·D H Skuse
Sep 7, 2007·Annual Review of Entomology·Reuven Dukas
Apr 8, 1998·Annual Review of Neuroscience·J Dubnau, T Tully
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Dukas, E A Bernays
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Frederic Mery, Tadeusz J Kawecki
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kuen J TsaiEminy H Y Lee
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-Rakic
Jul 30, 2003·Genes, Brain, and Behavior·R W WilliamsW E Crusio
Jul 12, 2008·Archives of Insect Biochemistry and Physiology·Yi-Ling ChenEn-Cheng Yang
Nov 26, 2010·The EMBO Journal·Derek J C TaiEminy H Y Lee
Nov 4, 2005·Progress in Neurobiology·Sean E McGuireRonald L Davis
Nov 2, 2014·Animal Cognition·Theodora Fuss, Vera Schluessel
Oct 21, 1999·Journal of Theoretical Biology·R Holliday
May 17, 2018·Evolution; International Journal of Organic Evolution·Maartje LieftingJacintha Ellers
Jun 4, 2002·Nature Genetics·J Steven de Belle
Jun 20, 2020·Genome Génome / Conseil National De Recherches Canada·Taylor BarwellLaurent Seroude
Aug 14, 2002·British Journal of Anaesthesia·H A Nash
Feb 21, 2003·Current Biology : CB·Josh DubnauTim Tully
Aug 22, 2003·Genetics·Indrani GangulyRobert R H Anholt
Jul 1, 1997·Learning & Memory·A Guo, K G Götz

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