Apr 28, 2017

Discovery of LHRH and development of LHRH analogs for prostate cancer treatment

The Prostate
Andrew V SchallyFerenc G Rick

Abstract

The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone-releasing hormone (LHRH), which regulates reproduction, is briefly described. The design, synthesis, and experimental and clinical testing of agonistic analogs of LHRH is extensively reviewed focusing on the development of new methods for the treatment of prostate cancer. Subsequent development of antagonistic analogs of LHRH is then faithfully recounted with special emphasis on therapy of prostate cancer and BPH. The concepts of targeted therapy to peptide receptors on tumors are re-examined and the development of the cytotoxic analogs of LHRH and their status is reviewed. The endeavor to develop better therapies for prostate cancer, based on LHRH analogs, guided much of our work.

  • References122
  • Citations3

References

  • References122
  • Citations3

Citations

Mentioned in this Paper

Prostatic Neoplasms
Antineoplastic Agents
Gonadotropin Hormone-releasing Hormone Activity
TNM Staging System
Isolation Aspects
Analog
Neoplasms
Prostate Carcinoma
Regulation of Reproductive Process
Peptide Receptor

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