Discovery of LHRH and development of LHRH analogs for prostate cancer treatment

The Prostate
Andrew V SchallyFerenc G Rick

Abstract

The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone-releasing hormone (LHRH), which regulates reproduction, is briefly described. The design, synthesis, and experimental and clinical testing of agonistic analogs of LHRH is extensively reviewed focusing on the development of new methods for the treatment of prostate cancer. Subsequent development of antagonistic analogs of LHRH is then faithfully recounted with special emphasis on therapy of prostate cancer and BPH. The concepts of targeted therapy to peptide receptors on tumors are re-examined and the development of the cytotoxic analogs of LHRH and their status is reviewed. The endeavor to develop better therapies for prostate cancer, based on LHRH analogs, guided much of our work.

References

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Citations

Nov 11, 2017·Frontiers in Endocrinology·Colleen A Flanagan, Ashmeetha Manilall
Oct 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew V SchallyXianyang Zhang
Oct 22, 2019·Frontiers in Oncology·Maira Huerta-ReyesArturo Aguilar-Rojas
Mar 31, 2019·Molecular Cancer Therapeutics·Shaolin MaAnil K Sood
Feb 6, 2021·Nature Reviews. Disease Primers·Richard J RebelloRobert G Bristow
Feb 8, 2020·General and Comparative Endocrinology·José A Muñoz-CuetoYonathan Zohar

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