Discovery of LHRH and development of LHRH analogs for prostate cancer treatment

The Prostate
Andrew V SchallyFerenc G Rick


The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone-releasing hormone (LHRH), which regulates reproduction, is briefly described. The design, synthesis, and experimental and clinical testing of agonistic analogs of LHRH is extensively reviewed focusing on the development of new methods for the treatment of prostate cancer. Subsequent development of antagonistic analogs of LHRH is then faithfully recounted with special emphasis on therapy of prostate cancer and BPH. The concepts of targeted therapy to peptide receptors on tumors are re-examined and the development of the cytotoxic analogs of LHRH and their status is reviewed. The endeavor to develop better therapies for prostate cancer, based on LHRH analogs, guided much of our work.


Apr 1, 1979·Clinical Endocrinology·J A WassA V Schally
Nov 17, 1975·Biochemical and Biophysical Research Communications·D H CoyA V Schally
Jul 1, 1992·The Journal of Clinical Endocrinology and Metabolism·P LimontaM Motta
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A LjungqvistK Folkers
Dec 1, 1988·International Journal of Peptide and Protein Research·S BajuszA V Schally
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
May 1, 1988·Journal of Inorganic Biochemistry·K GeregaB Rzeszotarska
Jun 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R AhmannD L Trump
Apr 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A J KastinA Arimura
Nov 1, 1972·Biochemical and Biophysical Research Communications·M FujinoT Fukuda
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·A J KastinD S Schalch
Aug 19, 1974·Biochemical and Biophysical Research Communications·J A Vilchez-MartinezA V Schally
Sep 9, 1974·Biochemical and Biophysical Research Communications·M FujinoI Yamazaki
Oct 1, 1974·Clinical Endocrinology·A ArimuraA V Schally
Aug 1, 1969·The Journal of Clinical Endocrinology and Metabolism·A J KastinA Diaz-Infante
Apr 16, 1971·Biochemical and Biophysical Research Communications·A V SchallyL Debeljuk
Jun 18, 1971·Biochemical and Biophysical Research Communications·H MatsuoA V Schally
Nov 5, 1971·Biochemical and Biophysical Research Communications·H MatsuoA V Schally
Jul 1, 1968·The Journal of Clinical Endocrinology and Metabolism·C Y BowersA Parlow
Nov 6, 1969·Biochemical and Biophysical Research Communications·J BolerA V Schally
May 1, 1970·Endocrinology·C Y BowersK Folkers

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Nov 11, 2017·Frontiers in Endocrinology·Colleen A Flanagan, Ashmeetha Manilall
Oct 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew V SchallyXianyang Zhang
Oct 22, 2019·Frontiers in Oncology·Maira Huerta-ReyesArturo Aguilar-Rojas
Mar 31, 2019·Molecular Cancer Therapeutics·Shaolin MaAnil K Sood
Feb 6, 2021·Nature Reviews. Disease Primers·Richard J RebelloRobert G Bristow
Feb 8, 2020·General and Comparative Endocrinology·José A Muñoz-CuetoYonathan Zohar

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