Discovery of new antidepressant agents: In vivo study on Anthemis wiedemanniana Fisch. & Mey

Journal of Ethnopharmacology
Fatma Tuğçe Gürağaç DereliEsra Küpeli Akkol

Abstract

Many of the currently available antidepressants have serious adverse effects and are also expensive. Traditional medicines are major sources of original drugs, and their role in effective treatment is remarkable. In Turkish folk medicine, decoctions and infusions are prepared from the flowers of Anthemis wiedemanniana Fisch. & Mey. They exert antispasmodic and sedative effects and are also used for treating urinary inflammations. The present study was designed to evaluate the antidepressant activity of A. wiedemanniana, which is used against central nervous system disorders in Turkish folk medicine. n-Hexane, ethyl acetate, and methanol (MeOH) extracts were prepared from the flowers of the plant. The antidepressant potentials of these extracts were evaluated in mouse models using the forced swimming test, tail suspension test, and antagonism of tetrabenazine-induced ptosis, hypothermia, and suppression of locomotor activity. The results were compared with those in control and reference groups, and active constituents of the plant were determined. The MeOH extract of A. wiedemanniana was subjected to various chromatographic separation techniques, leading to the isolation and identification of the active component(s). After confi...Continue Reading

Citations

May 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Esra Küpeli AkkolMert Ilhan
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fatma Tuğçe Gürağaç DereliEsra Küpeli Akkol
Nov 15, 2018·CNS & Neurological Disorders Drug Targets·Fatma Tuğçe Gürağaç DereliEsra Küpeli Akkol

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