Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

Neuroscience Letters
Fei SaSimon Ming Yuen Lee

Abstract

Dibenzocyclooctadiene lignans represent a unique group of natural chemical structures, are considered as protectants against neuronal cell death and cognitive impairment in neurological disorders. Among the family of dibenzocyclooctadiene lignan analogs from the fruit of Schisandra chinensis (Turcz.) Baill, neuroprotective potential of schisantherin A (StA) has not yet been characterized. In this study, 1-methyl-4-phenylpyridinium ion (MPP(+))-incubated SH-SY5Y cells and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice were used to study the neuroprotection of StA. Pretreatment with StA significantly inhibited MPP(+)-induced cytotoxicity in SH-SY5Y cells. Moreover, StA conferred significant protection against MPTP-induced loss of TH-positive dopaminergic neurons in a Parkinson's disease (PD) mice model. Structure activity relationship analysis suggested that methylenedioxy, benzoyloxy and methoxyl groups, in the dibenzocyclooctadiene lignan of StA, were probably functionally important to its neuroprotective activity. In addition, Western blotting analysis demonstrated that StA exhibited neuroprotection against MPP(+) through the regulation of two distinct pathways including increasing CREB-mediated Bcl-2 express...Continue Reading

References

Dec 15, 2005·Chemical Reviews·Junbiao ChangJingxi Xie
Jul 1, 2003·Expert Review of Neurotherapeutics·Kieran D O Malley, Linda Storoz
Sep 11, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tae Hwa LeeDae-Hee Lee
Nov 16, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Daping XuSimon MingYuen Lee

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Citations

Oct 11, 2015·Neuropharmacology·Yanwei LiChristian Hölscher
Jul 11, 2018·International Journal of Molecular Sciences·Minyu ZhangHongjun Yang
May 28, 2019·Current Medicinal Chemistry·Ze WangJing-Shan Shi
Sep 2, 2017·ACS Chemical Neuroscience·Enrico ZanforlinGiovanni Ribaudo

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