Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents

Bioorganic & Medicinal Chemistry Letters
Shaoyong KeZiwen Yang

Abstract

A series of isatin-dehydroepiandrosterone hybrids were synthesised via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly obtained compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), melanoma (A875) and 5-fluorouracil-resistant human hepatocellular carcinoma (BEL-7402/5-FU) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of highly potential anticancer agents.

References

Feb 5, 2011·Steroids·Gustav WaschatkoKatja Gehrig-Burger
Apr 4, 2013·Anti-cancer Agents in Medicinal Chemistry·Shaoyong KeZiwen Yang
May 3, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mohsen VosooghiAlireza Foroumadi
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Dec 2, 2018·Future Medicinal Chemistry·Shaoyong KeYanhong Wei
Sep 3, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Shaoyong KeLiqiao Shi
Jan 22, 2020·Archiv der Pharmazie·Zhen DingCheng Zeng
Jul 22, 2018·Current Medicinal Chemistry·Aysegul HanikogluTomris Ozben
Jan 1, 2018·Chemistry of Natural Compounds·N Sh NadaraiaU S Makhmudov
Jun 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed El-NaggarHatem A Abdel-Aziz
Sep 26, 2020·Current Organic Synthesis·Garima ChauhanShaik Khasimbi
Nov 20, 2019··Muhammad Riza Ghulam FahmiLeny Yuliati

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