Discovery of oxathiapiprolin, a new oomycete fungicide that targets an oxysterol binding protein

Bioorganic & Medicinal Chemistry
Robert J PasterisRichard A Berger

Abstract

Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens. It acts via inhibition of a novel fungal target-an oxysterol binding protein-resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont™ Zorvec™ disease control with first registration and sales anticipated in 2015. The discovery, synthesis, optimization and biological efficacy are presented.

Citations

Jan 5, 2016·Bioorganic & Medicinal Chemistry·Stephane JeanmartMartin Pouliot
Oct 22, 2016·Pest Management Science·Ann M BuysseXinpei Huang
Dec 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuebo ZhangYun Ling
Oct 11, 2017·Topics in Current Chemistry·Ponnam Devendar, Guang-Fu Yang
Mar 10, 2018·Environmental Microbiology Reports·Jianqiang MiaoBrett M Tyler
Apr 29, 2018·Pest Management Science·Peter Jeschke
Jul 28, 2019·Pest Management Science·Behrooz MoosaviGuang-Fu Yang
Feb 16, 2020·International Journal of Molecular Sciences·Qin PengYe Xia
Aug 28, 2019·Plant Disease·Ryan M HumannSamuel G Markell
Dec 11, 2019·Biomolecules·Vladimir N Uversky, Alexei V Finkelstein
Oct 11, 2017·Pest Management Science·Clemens Lamberth
Nov 3, 2020·Journal of Pesticide Science·Noriharu Umetsu, Yuichi Shirai
May 12, 2020·Bioorganic & Medicinal Chemistry Letters·Shaoyong KeDaye Huang
Mar 13, 2021·Journal of Agricultural and Food Chemistry·Yingying GaoMinghua Wang
Mar 26, 2021·Journal of Agricultural and Food Chemistry·Jianqiang MiaoXili Liu
Apr 26, 2021·Bioorganic & Medicinal Chemistry·Stephane JeanmartJames A Morris
May 14, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·T A AndersonM A Mutschler
Jan 15, 2019·Journal of Agricultural and Food Chemistry·Qifan WuFan Chen
Oct 5, 2021·Journal of Agricultural and Food Chemistry·Weizhen WangXili Liu
Oct 31, 2021·Pest Management Science·Mamadou Kane MboupJean-Luc Genet
May 12, 2021·Phytopathology·Pruthvi B KalyandurgRamesh R Vetukuri

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