Discovery of Point Mutations in the Voltage-Gated Sodium Channel from African Aedes aegypti Populations: Potential Phylogenetic Reasons for Gene Introgression

PLoS Neglected Tropical Diseases
Hitoshi KawadaNoboru Minakawa


Yellow fever is endemic in some countries in Africa, and Aedes aegpyti is one of the most important vectors implicated in the outbreak. The mapping of the nation-wide distribution and the detection of insecticide resistance of vector mosquitoes will provide the beneficial information for forecasting of dengue and yellow fever outbreaks and effective control measures. High resistance to DDT was observed in all mosquito colonies collected in Ghana. The resistance and the possible existence of resistance or tolerance to permethrin were suspected in some colonies. High frequencies of point mutations at the voltage-gated sodium channel (F1534C) and one heterozygote of the other mutation (V1016I) were detected, and this is the first detection on the African continent. The frequency of F1534C allele and the ratio of F1534C homozygotes in Ae. aegypti aegypti (Aaa) were significantly higher than those in Ae. aegypti formosus (Aaf). We could detect the two types of introns between exon 20 and 21, and the F1534C mutations were strongly linked with one type of intron, which was commonly found in South East Asian and South and Central American countries, suggesting the possibility that this mutation was introduced from other continents or c...Continue Reading


Dec 18, 2002·Journal of Molecular Evolution·Anna-Bella FaillouxFrançois Rodhain
Mar 10, 2004·Bulletin of Mathematical Biology·Yunxin HuangFrank van den Bosch
May 30, 2007·Pest Management Science·Ralf Nauen
Jan 12, 1934·Science·C I Bliss
Mar 11, 2009·PLoS Neglected Tropical Diseases·Hitoshi KawadaMasahiro Takagi
Sep 9, 2009·Tropical Medicine & International Health : TM & IH·Ademir Jesus MartinsDenise Valle
Aug 5, 2010·The American Journal of Tropical Medicine and Hygiene·Angela F HarrisHilary Ranson
Jan 5, 2011·Insect Biochemistry and Molecular Biology·Nongkran LumjuanHilary Ranson
Feb 15, 2012·Journal of the American Mosquito Control Association·Quetzaly SillerAdriana E Flores
May 3, 2012·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Andreas Adutwum KudomThomas Kwaku Agyemang
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jan 17, 2014·Parasites & Vectors·Jutta Gerlinde Birggitt LinssAdemir Jesus Martins
Jan 30, 2014·Memórias do Instituto Oswaldo Cruz·Gonçalo SeixasCarla Alexandra Sousa
Mar 4, 2014·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Massamba SyllaWilliam C Black
Nov 14, 2014·Nature·Carolyn S McBrideLeslie B Vosshall
Jan 15, 2015·The American Journal of Tropical Medicine and Hygiene·Justin StolerGordon A Awandare
Dec 15, 2015·PLoS Neglected Tropical Diseases·Farah Z Vera-MaloofWilliam C Black Iv


Jul 21, 2017·PLoS Neglected Tropical Diseases·Catherine MoyesDavid Weetman
Feb 1, 2018·International Journal of Environmental Research and Public Health·David WeetmanP J McCall
May 24, 2019·PLoS Neglected Tropical Diseases·Athanase BadoloDavid Weetman
Apr 17, 2020·PLoS Neglected Tropical Diseases·Luciano Veiga CosmeAdemir Jesus Martins
Apr 18, 2020·PLoS Neglected Tropical Diseases·Yinjun FanJeffrey G Scott
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
May 9, 2020·PLoS Neglected Tropical Diseases·Constância F J AyresCarla Alexandra Sousa
Jun 23, 2020·PLoS Neglected Tropical Diseases·Alessandra TancrediMariangela Bonizzoni

Related Concepts

Mosquito Vectors
Insecticide Resistance
Point Mutation
Voltage-Gated Sodium Channels