Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists

Journal of Medicinal Chemistry
Simon E WardJeannette M Watson

Abstract

5-HT1 receptor antagonists have been discovered with good selectivity over the 5-HT transporter. This is the first report of highly potent, selective ligands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of molecules for further understanding the roles of the 5-HT1 receptor subtypes and providing new approaches for the treatment of depression.

References

Jun 1, 2000·The Journal of Clinical Psychiatry·R M HirschfeldM Bourgeois
Dec 26, 2001·Brain Research Bulletin·C RobertsD N Middlemiss
Jan 25, 2005·Bioorganic & Medicinal Chemistry Letters·Peter J AtkinsonJeannette M Watson
Jan 29, 2005·British Journal of Pharmacology·Tania O SteanNeil Upton
May 13, 2005·Journal of Medicinal Chemistry·Simon E WardJeannette M Watson
Nov 30, 2006·Bioorganic & Medicinal Chemistry Letters·Peter J LovellJeannette M Watson
Jul 17, 2007·Bioorganic & Medicinal Chemistry Letters·Simon E WardJeannette M Watson

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Citations

Apr 30, 2013·Journal of Computer-aided Molecular Design·Tony NgoRenate Griffith
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mark J Millan
Oct 4, 2011·Acta Pharmacologica Sinica·Xue-lian ZhuWei-liang Zhu
Jun 21, 2011·Journal of Pharmacy & Bioallied Sciences·Nadeem SiddiquiRajiv Kumar

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