Discovery of powerful uranyl ligands from efficient synthesis and screening

Chemistry : a European Journal
Marcin SawickiFrédéric Taran

Abstract

New tripodal gem-(bis-phosphonates) uranophiles were discovered by a screening method that allowed for the selection of ligands with strong uranyl-binding properties in a convenient microtiter-plate format. The method is based on competitive uranium binding by using Sulfochlorophenol S as chromogenic chelate. This dye compound was found to present high uranyl complexation properties and allowed to highlight ligands presenting association constants for UO(2+)(2) up to 10(18) at pH 7.4 and 10(20) at pH 9. A collection of 40 known ligands including polycarboxylate, hydroxamate, catecholate, hydroxypyridonate and hydroxyquinoline derivatives was tested. Also screened was a combinatorial library prepared from seven amine scaffolds and eight acrylates bearing diverse chelating moieties. Among these 96 tested candidates, a tripod derivative bearing gem-bis-phosphonates moieties was found to present the highest complexation properties over a wide range of pH and was further studied.

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Citations

Feb 7, 2017·Chemistry : a European Journal·Matthieu StarckPascale Delangle
Jun 25, 2015·Chemical Communications : Chem Comm·Chu-Ting YangXiaolin Wang
Dec 14, 2006·Health Physics·Satoshi FukudaYuyuan Xie
Sep 5, 2017·Chemistry : a European Journal·Sandrine Sauge-MerleCatherine Berthomieu
Oct 18, 2014·Chemistry : a European Journal·Colette LebrunPascale Delangle

Related Concepts

Sulfochlorophenol S
Hydrogen-Ion Concentration
Ligands
Naphthalenes
Organometallic Compounds
Sulfones
Uranium

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