Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria

Journal of the American Chemical Society
Kenichi MatsudaMakoto Nishiyama

Abstract

Recent studies described several different routes that facilitate nitrogen-nitrogen bond formation in natural product biosynthesis. We report herein the identification of unprecedented machinery for hydrazine formation involved in the biosynthesis of s56-p1, a dipeptide natural product with a unique hydrazone unit. The gene cassette comprising this machinery is widespread across several bacterial phyla, highlighting the overlooked potential of bacteria to synthesize hydrazine.

References

Jun 12, 2002·Biochemistry·Ruchi AnandSteven E Ealick
Sep 13, 2005·Nature Structural & Molecular Biology·Kotaro NakanishiOsamu Nureki
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Danica Galonic FujimoriChristopher T Walsh
May 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ram P GargRonald J Parry
Jun 25, 2009·Journal of the American Chemical Society·Ram P GargRonald J Parry
Apr 24, 2012·Chembiochem : a European Journal of Chemical Biology·Christopher S NeumannChristopher T Walsh
Apr 13, 2013·Journal of Natural Products·Lachlan M Blair, Jonathan Sperry
May 8, 2013·Chembiochem : a European Journal of Chemical Biology·Roland D KerstenBradley S Moore
Aug 6, 2013·Chemistry & Biology·Yi-Ling DuKatherine S Ryan
Jul 22, 2014·Tetrahedron·Jeffrey E JansoEmily P Balskus
Dec 3, 2014·Bioorganic & Medicinal Chemistry·Géraldine Le Goff, Jamal Ouazzani
Jan 27, 2015·Chemical Science·Zedu HuangWilfred A van der Donk
Aug 19, 2015·Chembiochem : a European Journal of Chemical Biology·Abraham J WaldmanEmily P Balskus
Dec 23, 2015·Nature Chemical Biology·Yoshinori SugaiYasuo Ohnishi
Jan 11, 2017·Chemical Science·Zedu HuangWilfred A van der Donk
Apr 5, 2017·Chemical Reviews·Abraham J WaldmanEmily P Balskus
Jun 20, 2017·Nature Chemical Biology·Yi-Ling DuKatherine S Ryan
May 18, 2018·The Journal of Organic Chemistry·Abraham J Waldman, Emily P Balskus

❮ Previous
Next ❯

Citations

Sep 14, 2018·Natural Product Reports·Robert A Hill, Andrew Sutherland
Sep 27, 2019·The Journal of Antibiotics·Taro Shiraishi, Tomohisa Kuzuyama
Oct 24, 2019·Chembiochem : a European Journal of Chemical Biology·Tai L NgEmily P Balskus
Dec 12, 2019·Angewandte Chemie·Menghua WangKatherine S Ryan
Sep 5, 2019·Chembiochem : a European Journal of Chemical Biology·Guiyun ZhaoYi-Ling Du
Jun 26, 2020·Organic & Biomolecular Chemistry·Sumire KurosawaMakoto Nishiyama
Jun 7, 2020·Applied Microbiology and Biotechnology·Carolin MüggeDirk Tischler
Dec 28, 2018·Chembiochem : a European Journal of Chemical Biology·Frederick F TwiggWenjun Zhang
Oct 9, 2019·Nature Communications·Yuan-Yang GuoYong-Quan Li
Apr 2, 2020·Nature Reviews. Chemistry·Thomas A Scott, Jörn Piel
Apr 3, 2020·Nature Communications·Guiyun ZhaoYi-Ling Du
Sep 13, 2018·Nature Communications·Kwo-Kwang A WangWilfred A van der Donk
Jan 16, 2019·Nature Communications·Zhijuan HuIkuro Abe
Feb 16, 2021·Biotechnology Advances·Caroline E PaulWillem J H van Berkel
Mar 16, 2021·ACS Chemical Biology·Linyue ChenChangming Zhao
May 7, 2021·Chemical & Pharmaceutical Bulletin·Takayoshi Awakawa
Dec 24, 2019·Chemical Reviews·Jason B Hedges, Katherine S Ryan
Feb 15, 2019·Journal of the American Chemical Society·Hai-Yan HeKatherine S Ryan
Nov 17, 2020·Journal of Natural Products·Mario Wibowo, Ling Ding
Nov 3, 2021·Nature Chemical Biology·Antonio Del Rio FloresWenjun Zhang
Jan 22, 2022·Journal of the American Chemical Society·Guang-Lei MaZhao-Xun Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved