Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Bioorganic & Medicinal Chemistry Letters
Raul R CalvoMark R Player

Abstract

Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described.

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Citations

Oct 9, 2013·Annual Review of Cell and Developmental Biology·David Julius
Jan 21, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·S KambizE T Walbeehm
Oct 10, 2013·British Journal of Pharmacology·Yosuke Kaneko, Arpad Szallasi
Jun 7, 2012·Expert Opinion on Therapeutic Patents·Delia PretiRiccardo Patacchini
Mar 19, 2013·European Journal of Pharmacology·Jill-Desiree BredersonArpad Szallasi
Jul 21, 2016·Journal of Medicinal Chemistry·M Jesús Pérez de VegaRosario González-Muñiz
Mar 31, 2017·Pharmaceuticals·Andy D Weyer, Sonya G Lehto
Jan 30, 2014·The Journal of Pharmacology and Experimental Therapeutics·Ryan PatelAnthony H Dickenson
Jan 23, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Robyn J Laing, Ajay Dhaka
Sep 9, 2017·Scientific Reports·Roberto de la Torre-MartínezRosario González-Muñiz
Nov 17, 2020·Frontiers in Immunology·Harold A SilvermanEric H Chang

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