Discrepancies among CT, histological, and blood-brain barrier findings in early cerebral ischemia

Journal of Neurosurgery
T KuroiwaY Inaba

Abstract

The development of ischemic edema and blood-brain barrier (BBB) disruption during the 1st day of experimental cerebral infarction induced by transorbital occlusion of the middle cerebral artery (MCA) in cats was evaluated by computerized tomography (CT) scanning and compared to gravimetric and pathological studies. Regional cerebral blood flow was measured using the hydrogen clearance technique or stable xenon-enhanced CT scanning. Edema was observed gravimetrically and microscopically as early as 1 hour after the onset of ischemia in the cortex and at 3 hours or later in both the cortex and white matter. However, a significant decrease of Hounsfield numbers on the CT scans was not detectable at 1 or 3 hours and was scarcely visible at 9 hours after occlusion. Disruption of the BBB was detected by leakage of Evans blue dye at 3 hours after the occlusion in two of six animals and at 9 hours in five of five animals. However, CT scanning after infusion of contrast material showed no significant increase in Hounsfield number even 24 hours after MCA occlusion. These discrepancies should be emphasized when the dynamics of ischemic edema and BBB disruption are evaluated for clinical therapy by CT scanning.

References

Nov 1, 1978·AJR. American Journal of Roentgenology·G A NortonJ Lin
May 1, 1985·Journal of Neurosurgery·P PicozziA H Crockard
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L JunckD A Rottenberg
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·J H Garcia
Jul 1, 1981·Stroke; a Journal of Cerebral Circulation·J S MeyerY Harati
Mar 1, 1982·Stroke; a Journal of Cerebral Circulation·L ShabasonH Yonas
Jan 1, 1982·Computerized Radiology : Official Journal of the Computerized Tomography Society·R M Torack
Jul 1, 1982·Journal of Neurosurgery·T ShigenoJ Cervós-Navarro

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Citations

Sep 1, 1996·Journal of Magnetic Resonance Imaging : JMRI·M M BahnD T Cross
Jul 26, 1988·European Journal of Pharmacology·T TerawakiY Masuda
Oct 4, 2005·Neuroimaging Clinics of North America·Thomas Kucinski
Apr 11, 2000·Neurologic Clinics·R J Wityk, N J Beauchamp
Aug 1, 1994·Stroke; a Journal of Cerebral Circulation·G Y Yang, A L Betz
Jan 1, 1992·Stroke; a Journal of Cerebral Circulation·J J KohutC E Gross
Jan 1, 1994·Neurosurgery·P J CamarataR E Latchaw

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Methods Mentioned

BETA
electron
light microscopy

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