Discrepancies of NKT cells expression in peripheral blood and in cerebrospinal fluid from Behçet's disease

Journal of Neuroimmunology
Kamel HamzaouiAgnes Hamzaoui

Abstract

The precise role of natural killer T (NKT) cells in the pathogenesis of Behçet's disease (BD) remains unknown. The frequency, cytokine profile and heterogeneity of NKT cells were studied in peripheral blood mononuclear cells (PBMC) from 42BD patients and in cerebrospinal fluid (CSF) samples from 9 neuro-BD patients. Flow cytometry revealed a decreased frequency of NKT cells in PBMC from BD patients (median: 0.06%; range: 0%-0.3%) when compared to healthy controls (median: 0.23%; range: 0.1%-0.7%; P<0.01). NKT cells were biased toward a Th(1)-like phenotype, with a significant decrease of IL-4/IFN-gamma ratio in BD (median: 0.049; range: 0.01-0.13) vs. healthy controls (median: 0.82; range: 0.4-1.33; P<0.01). NKT cells were increased in CSF-BD samples (median: 0.18%; range: 0.1%-0.4%), when compared to CSF-NIND patients (median: 0.05%; range: 0.01%-0.09%; P<0.01). Based on the reactivity of PBMC-derived NKT cells toward alpha-galactosylceramide (alpha-GalCer), 80% of BD patients were non-responsive. At the opposite, the reactivity of NKT cells in CSF from BD patients was not impaired. BD-CSF NKT cells exhibited an increased expression of IFN-gamma-producing cells, demonstrating that CSF-NKT cells were functional, and biased towa...Continue Reading

References

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Jul 26, 2005·Journal of Neuroimmunology·Yasushi SuzukiYasuto Itoyama

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Citations

Sep 26, 2015·Rheumatology International·Durga Prasanna Misra, Vikas Agarwal
Nov 7, 2006·Scandinavian Journal of Immunology·K HamzaouiH Houman
Jun 15, 2007·Journal of Neuroimmunology·Kamel HamzaouiAgnes Hamzaoui
Apr 6, 2013·Multidisciplinary Respiratory Medicine·Kamel HamzaouiAgnès Hamzaoui

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