Discrepancy between cardiac and physical functional reserves in stroke.

Stroke; a Journal of Cerebral Circulation
Djordje G JakovljevicMichael I Trenell

Abstract

Understanding the physiological limitations to exercise after stroke will assist the development of targeted therapies to improve everyday function. This study defines (1) whether exercise capacity is limited by the cardiovascular system (oxygen supply) or skeletal muscles (oxygen utilization); and (2) cardiac function and pumping capability in people with stroke. Twenty-eight male participants with mild ischemic stroke (70 ± 6 years of age, 18 ± 20 months poststroke) and 25 male, age-matched healthy control subjects performed a graded cardiopulmonary exercise test with gas exchange and noninvasive hemodynamic measurements. Maximal oxygen extraction was calculated as the ratio between peak oxygen consumption and peak cardiac output. Cardiac function and pumping capability were assessed by peak exercise cardiac power output (expressed in watts) and cardiac output. Peak oxygen consumption (18.4 ± 4.6 versus 26.8 ± 5.5 mL/kg/min, P<0.01) and arterial-venous O(2) difference (9.3 ± 2.5 versus 12.6 ± 1.9 mlO(2)/100 mL of blood, P<0.01) were both reduced in stroke participants compared with healthy control subjects. In contrast, peak exercise cardiac power output (4.79 ± 0.79 versus 4.51 ± 0.96 W, P=0.49), cardiac output (16.4 ± 3.1 v...Continue Reading

References

Mar 1, 2005·Topics in Stroke Rehabilitation·F M IveyC E Hafer-Macko
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Fred RinconMitchell S V Elkind
Aug 16, 2008·Stroke; a Journal of Cerebral Circulation·Corey R TomczakPatricia J Manns
Aug 23, 2008·International Journal of Cardiology·David F GoldspinkN Timothy Cable
May 16, 2009·Stroke; a Journal of Cerebral Circulation·Jiangyong MinArshad Majid

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Citations

Jan 15, 2016·Archives of Physical Medicine and Rehabilitation·Sarah A MooreMichael I Trenell
Sep 16, 2015·Journal of Neurologic Physical Therapy : JNPT·Pierce BoyneKari Dunning
Mar 31, 2015·Archives of Physical Medicine and Rehabilitation·Johan GäverthMarilyn MacKay-Lyons
Jun 8, 2013·International Journal of Cardiology·Matthew G D BatesGráinne S Gorman
May 18, 2016·Journal of Physical Therapy Science·Janaine Cunha PoleseLuci F Teixeira-Salmela
Jun 30, 2012·Stroke; a Journal of Cerebral Circulation·Corey R Tomczak, Mark J Haykowsky
Nov 8, 2018·Brain Injury : [BI]·Birgitta Langhammer, Johan K Stanghelle
May 25, 2021·Topics in Stroke Rehabilitation·Esra Mustafa, Yesim Kurtais Aytür
Jun 19, 2021·Scientific Reports·Kazuaki OyakeKimito Momose

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