Discrepancy between the Recommended and Functional Cut Offs of Vitamin D among Under-five Children: Experiences from a Pilot Study

Indian Journal of Endocrinology and Metabolism
Suchitra SurveBeena Joshi

Abstract

Vitamin D is a key determinant of bone health and calcium homeostasis in children. Vitamin D deficiency (VDD) in early years may have an effect on total bone mass and risk of osteoporosis. Despite widespread prevalence of VDD among children, there is limited information in under-five age group. The objectives of the current study were to estimate the community-based prevalence of VDD and to identify the factors associated with children aged 1-5 years. A community-based cross-sectional study was conducted among 201 apparently healthy children (aged 1-5 years) in an urban slum of the selected geographical area in Mumbai. VDD was defined as serum 25-hydroxy Vitamin D (25[OH]D) levels <20 ng/ml as per the US Endocrine society classification. The prevalence of VDD was found to be 74.6% (95% of confidence interval [68.6-80.6]). It was significantly higher (P = 0.04) among children staying indoors (44.8%). 25(OH)D was negatively correlated with parathyroid hormone (PTH) ([r = -0.199, P = 0.005]) and Alkaline phosphatase ([r = -0.140, P = 0.05]). However, the increase in PTH was observed when 25(OH)D levels were <10 ng/ml unlike anticipated increase at <20 ng/ml. The study revealed a high prevalence of VDD in 1-5 years age group. It wa...Continue Reading

Citations

Apr 20, 2021·Indian Journal of Clinical Biochemistry : IJCB·Suchitra SurveSanjay Chauhan

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