Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia

Journal of Alzheimer's Disease : JAD
Ryszard PlutaStanisław J Czuczwar

Abstract

Brain ischemia may be causally related with Alzheimer's disease. Presumably, β-secretase and amyloid-β protein precursor gene expression changes may be associated with Alzheimer's disease neuropathology. Consequently, we have examined quantitative changes in both β-secretase and amyloid-β protein precursor genes in the medial temporal lobe cortex with the use of quantitative rtPCR analysis following 10-min global brain ischemia in rats with survival of 2, 7, and 30 days. The greatest significant overexpression of β-secretase gene was noted on the 2nd day, while on days 7-30 the expression of this gene was only modestly downregulated. Amyloid-β protein precursor gene was downregulated on the 2nd day, but on days 7-30 postischemia, there was a significant reverse tendency. Thus, the demonstrated alterations indicate that the considerable changes of expression of β-secretase and amyloid-β protein precursor genes may be connected with a response of neurons in medial temporal lobe cortex to transient global brain ischemia. Finally, the ischemia-induced gene changes may play a key role in a late and slow onset of Alzheimer-type pathology.

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Citations

Oct 7, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
Feb 15, 2019·Neural Regeneration Research·Ryszard Pluta, Marzena Ułamek-Kozioł
May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Oct 5, 2018·Journal of Alzheimer's Disease : JAD·Ryszard PlutaStanisław J Czuczwar
Feb 6, 2020·International Journal of Molecular Sciences·Marzena Ułamek-KoziołRyszard Pluta
Sep 29, 2020·Frontiers in Neurology·Hae Won KimJae Cheon Jeon
Dec 14, 2018·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jul 2, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Mar 9, 2021·Frontiers in Aging Neuroscience·Ryszard PlutaStanisław J Czuczwar
May 1, 2021·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jul 3, 2021·Frontiers in Aging Neuroscience·Sanghamitra Bandyopadhyay

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