Discrepancy in Frailty Identification: Move Beyond Predictive Validity.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Qian-Li XueKaren Bandeen-Roche

Abstract

To evaluate the discordance in frailty classification between the frailty index (FI) and the physical frailty phenotype (PFP) and identify factors discriminating those with discordant frailty classification from each other and from those for whom the assessments agree. A prospective observational study of older adults aged 65 and older selected from Medicare eligibility lists in four U.S. communities (n = 5,362). The PFP was measured by the Cardiovascular Health Study PFP. Participants meeting three or more of the five criteria were deemed frail. The FI was calculated as the proportion of deficits in an a priori selected set of 48 measures, and participants were classified as frail if FI is greater than 0.35. The prevalence of frailty was 7.0% by the PFP and 8.3% by the FI. Of the 730 deemed frail by either instrument, only 12% were in agreement, whereas 39% were classified as frail by the PFP, but not the FI, and 48% were classified as frail by the FI, but not the PFP. Participants aged 65-72 years or with greater disease burden were most likely to be characterized as being FI-frail, but not PFP-frail. The associations of frailty with age and mortality were stronger when frailty was measured by the PFP rather than the FI. Desp...Continue Reading

References

Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A B NewmanUNKNOWN Cardiovascular Health Study Research Group
Mar 19, 2002·BMC Geriatrics·Arnold B MitnitskiKenneth Rockwood
Dec 2, 2005·Mechanisms of Ageing and Development·Petr Klemera, Stanislav Doubal
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth RockwoodArnold Mitnitski
May 21, 2009·Journal of the American Geriatrics Society·Christine T CigolleCaroline S Blaum
Dec 14, 2011·The Journal of Nutrition, Health & Aging·A MitnitskiK Rockwood
Jun 15, 2013·Journal of the American Medical Directors Association·John E MorleyJeremy Walston
Sep 14, 2013·Journal of the American Geriatrics Society·Olga TheouKenneth Rockwood
Jan 11, 2014·Journal of the American Medical Directors Association·Qian-Li Xue, Ravi Varadhan
Aug 13, 2015·BMC Medicine·Jeremy D Walston, Karen Bandeen-Roche
May 25, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arnold MitnitskiKenneth Rockwood

❮ Previous
Next ❯

Citations

Jul 4, 2020·Critical Care Medicine·Nathan E BrummelE Wesley Ely
Oct 12, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mara McAdams-DeMarcoDorry L Segev
Mar 21, 2021·Best Practice & Research. Clinical Anaesthesiology·Matthias Derwall, Mark Coburn
Jun 19, 2021·Journal of the American Medical Directors Association·Mauro Di BariDaniela Balzi
Jul 21, 2021·BMC Geriatrics·Ivan Aprahamian, Qian-Li Xue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.