PMID: 2506137Sep 15, 1989Paper

Discrepancy in the abilities of lymphokines and bacteria to mediate tumor protection in vivo and/or tumoricidal activity by macrophages in vitro

International Journal of Cancer. Journal International Du Cancer
R KellerR A Schwendener

Abstract

In the present study, the ability of lymphokines (MAF and IFN gamma) and microbial agents (CP and LM) to induce and maintain tumoricidal activity in BMMP in vitro and to enhance local resistance to the DA rat D-12 ascites tumor in vivo was assessed comparatively. Under standard conditions in vitro, i.e., when present during the 24-hr induction and the 36-hr effector phase, both lymphokines and microbes were similarly potent for eliciting tumoricidal activity in BMMP. When the activating agents were present only during the induction phase, and effector cells were interacted with tumor targets after a 24-hr interval, clear differences were observed: BMMP which had been incubated with lymphokines had largely if not completely lost their tumoricidal activity; in contrast, BMMP which had been incubated with microbes still manifested considerable tumoricidal activity. Experiments performed to assess the in vivo significance of the discrepancy established in vitro have shown that resistance to the D-12 ascites tumor was markedly enhanced after local inoculation of microbes but was affected very little or not at all by soluble lymphokines. The causes responsible for the discrepancy in the antitumor potential of lymphokines vs. microbes...Continue Reading

References

Dec 1, 1976·Journal of the National Cancer Institute·R Keller
Apr 15, 1989·Cellular Immunology·R KellerR Keist
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn
Oct 1, 1987·Annals of Internal Medicine·C E CrossD Harman
Jan 1, 1987·The New England Journal of Medicine·R K Oldham
Apr 3, 1971·Lancet·B M OgilvieR Keller
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histopathology·R Keller, M W Hess
Jan 1, 1980·Scandinavian Journal of Infectious Diseases·P Koskela, E Herva

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