Discrepancy of interleukin-6 levels between end-stage renal disease patients and patients with acute-phase response with increased lipoprotein(a) concentrations

Scandinavian Journal of Clinical and Laboratory Investigation
K A YunS H Hwang

Abstract

Though the concentration of serum lipoprotein(a) [Lp(a)] is mostly determined by genetic factors, secondary factors such as acute-phase response (APR) and end-stage renal disease (ESRD) also contribute to its increase. Lp(a) is known to be one of the acute-phase reactants and interleukin-6 (IL-6) is the key cytokine in the hepatic synthesis of acute-phase proteins. The serum concentrations of Lp(a) and IL-6 were measured in patients with APR and in patients with ESRD to investigate the relationship between Lp(a) and IL-6. A total of 180 patients were selected for the study: 60 patients were normal controls, 60 were patients with renal disease who had been on hemodialysis for more than 6 months [C-reactive protein (CRP)<4.0 mg/L], and 60 were APR patients who had a erythrocyte sedimentation rate (ESR) of over 50 mm/h. The three groups were age- and sex matched. The serum concentrations of Lp(a) and IL-6 were measured by ELISA. The serum concentrations of Lp(a) [median (interquartile range)] in normal controls, ESRD patients, and APR patients were 0.222 (0.103-0.364) g/L, 0.511 (0.308-0.755) g/L, and 0.546 (0.234-0.747) g/L, respectively; those of IL-6 were 1.0 (0.7-1.3) pg/mL, 2.1 (1.4-3.3) pg/mL, and 26.2 (15.2-35.6) pg/mL. The...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·E BoerwinkleH H Hobbs
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HattoriG H Fey
Nov 17, 1989·Science·G Utermann
Oct 1, 1995·Clinical and Experimental Immunology·R E BanksJ T Whicher
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P WadeR M Lawn
Jun 26, 1993·BMJ : British Medical Journal·H OlivecronaB Angelin
Aug 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·K M KostnerG M Kostner
Mar 1, 1997·The Journal of Pathology·H Moshage
Jan 15, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y KaizuH Kumagai
Jul 28, 1999·Seminars in Liver Disease·G Ramadori, B Christ

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