PMID: 6966400Mar 1, 1980Paper

Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

Proceedings of the National Academy of Sciences of the United States of America
E L ReinherzS F Schlossman

Abstract

A series of monoclonal antibodies was used to define three discrete stages of human intrathymic T-cell differentiation. The earliest stage was confined to <10% of thymocytes, which were.reactive with both OKT9 and OKT10. Subsequently, approximately 70% of human thymocytes acquired a thymocyte-restricted antigen, OKT6, lost OKT9 antigen, and expressed reactivity with OKT4 and OKT5. These last two monoclonal antibodies were previously shown to define inducer (helper) and cytotoxic/suppressor populations, respectively, in peripheral blood. The OKT4(+), OKT5(+), OKT6(+) "common" thymocyte population represents the majority of thymocytes and accounts for more than 70% of thymocytes. With further maturation, thymocytes lose OKT6 reactivity, segregate into OKT4(+) and OKT5(+) subsets, and acquire reactivity with OKT3 (and OKT1). This latter stage corresponds to the more functionally mature subset. The possible relationship of acute lymphoblastic leukemia of T-cell lineage to these proposed stages of intrathymic differentiation was determined. Analysis of 25 tumor populations showed that 21 could be related to one or another differentiative stage. The majority (15/21) were derived from an early thymocyte or prothymocyte subpopulation, ...Continue Reading

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May 10, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
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Citations

Jul 1, 1991·Journal of Cellular Biochemistry·J L BednarczykB W McIntyre
Jul 13, 2002·The Journal of Pathology·Mitsuyoshi HashimotoNaoyoshi Mori
Jan 6, 2000·Archives of Biochemistry and Biophysics·K M Khoo, C F Chang
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Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M DrijkoningenV Desmet
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Aug 15, 1983·Klinische Wochenschrift·F HerrmannH Rühl

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