Discriminable excitotoxic effects of ibotenic acid, AMPA, NMDA and quinolinic acid in the rat laterodorsal tegmental nucleus

Brain Research
W L Inglis, K Semba

Abstract

Excitotoxins are valuable tools in neuroscience research as they can help us to discover the extent to which certain neurones are necessary for different types of behaviour. They have distinctive neurotoxic effects depending on where they are infused, and this study was conducted to delineate the neurotoxic profiles of excitotoxins in the laterodorsal tegmental nucleus (LDTg). Two 0.1 microl infusions of 0.1 M ibotenate, 0.1 M quinolinate, 0.04-0.1 M NMDA, or 0.05-0.015 M AMPA, were made unilaterally into the LDTg under either pentobarbitone or Avertin anaesthesia. The injection needle was oriented at an angle of 24 degrees from vertical in the mediolateral plane. After 23-27 days, sections through the mesopontine tegmentum were processed using standard histological procedures for NADPH-diaphorase histochemistry, tyrosine hydroxylase or 5-hydroxytryptamine immunohistochemistry, and Cresyl violet. Lesions were assessed in terms of the size of the damaged area (identified by reactive gliosis), the extent of cholinergic cell loss in the mesopontine tegmentum (by counting NADPH-diaphorase-positive neurones), and neuronal loss induced in the locus coeruleus and dorsal raphe nucleus. Ibotenate induced compact lesions in the LDTg (mor...Continue Reading

References

Jun 1, 1979·The Journal of Physiology·D R CurtisH McLennan
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Aug 1, 1990·Brain Research Bulletin·J CornwallO T Phillipson
Nov 15, 1986·The Journal of Comparative Neurology·K Satoh, H C Fibiger
Aug 1, 1987·The Journal of Comparative Neurology·A E HallangerB H Wainer
Aug 22, 1988·The Journal of Comparative Neurology·A E Hallanger, B H Wainer
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Sep 1, 1967·Brain : a Journal of Neurology·C C Shute, P R Lewis
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·J C Watkins, R H Evans
Aug 1, 1994·Brain Research. Brain Research Reviews·T StecklerA Sahgal
Jul 1, 1994·Neuroscience Research·S YoshidaS Shiosaka

❮ Previous
Next ❯

Citations

Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·S R LavioletteJ S Yeomans
Jan 1, 2013·ISRN Neuroscience·Kristi A Kohlmeier
Dec 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christa J Van DortEmery N Brown
Sep 24, 2008·Autonomic Neuroscience : Basic & Clinical·W Michael PannetonQi Gan
Dec 14, 2011·Annals of Neurology·Luigi TitomanlioPierre Gressens
Sep 25, 2014·Journal of Neuroscience Research·Danijela BataveljicPavle Andjus
Oct 28, 1999·Neurobiology of Learning and Memory·E CoutureauG Di Scala
Jun 20, 2014·Behavioural Brain Research·Jelena PetrovicJasna Saponjic
Jun 25, 2005·Biochemical Pharmacology·Michael McKinney, Mayo Clinic Jacksonville
Feb 24, 2015·Cell Transplantation·Hueng-Chuen FanHorng-Jyh Harn
Nov 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bruce M KingBethany L Rollins
Apr 30, 2003·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·A D WrongA J Mercier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.