Jan 29, 2011

Discriminant analysis of longitudinal cortical thickness changes in Alzheimer's disease using dynamic and network features

Neurobiology of Aging
Yang LiAlzheimer's Disease Neuroimaging Initiative


Neuroimage measures from magnetic resonance (MR) imaging, such as cortical thickness, have been playing an increasingly important role in searching for biomarkers of Alzheimer's disease (AD). Recent studies show that, AD, mild cognitive impairment (MCI) and normal control (NC) can be distinguished with relatively high accuracy using the baseline cortical thickness. With the increasing availability of large longitudinal datasets, it also becomes possible to study the longitudinal changes of cortical thickness and their correlation with the development of pathology in AD. In this study, the longitudinal cortical thickness changes of 152 subjects from 4 clinical groups (AD, NC, Progressive-MCI and Stable-MCI) selected from Alzheimer's Disease Neuroimaging Initiative (ADNI) are measured by our recently developed 4 D (spatial+temporal) thickness measuring algorithm. It is found that the 4 clinical groups demonstrate very similar spatial distribution of grey matter (GM) loss on cortex. To fully utilize the longitudinal information and better discriminate the subjects from 4 groups, especially between Stable-MCI and Progressive-MCI, 3 different categories of features are extracted for each subject, i.e., (1) static cortical thickness ...Continue Reading

  • References39
  • Citations45


  • References39
  • Citations45


Mentioned in this Paper

Mini-mental State Examination
Familial Alzheimer Disease (FAD)
Biologic Segmentation
Memory Loss
Cerebral Atrophy
Cortex Bone Disorders
Abnormal Degeneration
Adrenal Cortex Diseases
Olfactory Cortex
Structure of Temporal Pole

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