Discriminated taste aversion with chlordiazepoxide

Pharmacology, Biochemistry, and Behavior
F Woudenberg, T H Hijzen


Discriminative stimulus effects have been studied extensively with the two-response, food-reinforced operant procedure and more recently also with discriminated taste aversion (DTA) procedures. DTA procedures have the advantage of a more rapid discrimination training. However, the test phase, i.e., drug substitution, of the DTA procedure is more time consuming (1 test per 4 days) than the test phase of the two-response procedure (2 tests per 5 days). The present study investigated whether a DTA procedure with 2 tests per 5 days could be implemented. In addition, the specificity of the DTA procedure was investigated. Rats were trained to discriminate chlordiazepoxide (CDP, 20 mg/kg, IP) from vehicle using a discriminated taste aversion procedure. Selective suppression of saccharin consumption after CDP injections was maximal after seven CDP-LiCl pairings. In subsequent substitution tests, with 2 tests per 5 days, CDP-mimicking effects were found only for another benzodiazepine, diazepam, and for a barbiturate, pentobarbital. The results indicate that rats can be rapidly trained to discriminate CDP from vehicle in the discriminated taste aversion procedure and that the CDP-cue so produced has the same specificity as in a two-resp...Continue Reading


Mar 13, 1990·European Journal of Pharmacology·F Woudenberg, J.L. Slangen
Jan 1, 1990·Journal of Experimental Psychology. Animal Behavior Processes·G M MartinD van der Kooy
Jan 1, 1989·Psychopharmacology·F Woudenberg, J.L. Slangen
Jan 1, 1985·Psychopharmacology·H S GarchaI P Stolerman
Jul 1, 1983·Pharmacology, Biochemistry, and Behavior·J S HendryJ A Rosecrans
May 21, 1982·European Journal of Pharmacology·T Haug, K G Götestam


Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A Van HestB Olivier
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, A L Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley

Related Concepts

Avoidance Learning
Discrimination (Process of Differentiation)
Psychotropic Drugs
August Rats
Taste Perception
Rats, Laboratory

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