Discriminating Malignancy in Thyroid Nodules: The Nomogram Versus the Kwak and ACR TI-RADS.

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Juan XiaoHongying Jia

Abstract

To develop an easy-to-use nomogram for discrimination of malignant thyroid nodules and to compare diagnostic efficiency with the Kwak and American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS). Retrospective diagnostic study. The Second Hospital of Shandong University. From March 2017 to April 2019, 792 patients with 1940 thyroid nodules were included into the training set; from May 2019 to December 2019, 174 patients with 389 nodules were included into the validation set. Multivariable logistic regression model was used to develop a nomogram for discriminating malignant nodules. To compare the diagnostic performance of the nomogram with the Kwak and ACR TI-RADS, the area under the receiver operating characteristic curve, sensitivity, specificity, and positive and negative predictive values were calculated. The nomogram consisted of 7 factors: composition, orientation, echogenicity, border, margin, extrathyroidal extension, and calcification. In the training set, for all nodules, the area under the curve (AUC) for the nomogram was 0.844, which was higher than the Kwak TI-RADS (0.826, P = .008) and the ACR TI-RADS (0.810, P < .001). For the 822 nodules >1 cm, the AUC of the nomogram was 0.891, w...Continue Reading

References

Sep 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Ji-Young ParkSeong Hun Kim
Mar 24, 2011·Head & Neck Oncology·Frederico F R MaiaDenise E Zantut-Wittmann
Jan 17, 2013·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jin Young KwakUNKNOWN Korean Society of Radiology
Mar 10, 2015·Thyroid : Official Journal of the American Thyroid Association·Luciana Reck RemontiJorge Luiz Gross
Jun 1, 2016·Lancet·Maria E CabanillasCosimo Durante
Apr 5, 2017·Journal of the American College of Radiology : JACR·Franklin N TesslerA Thomas Stavros
Jan 18, 2018·International Journal of Surgery·Kyle R JosephGuy D Eslick
Feb 1, 2019·Thyroid : Official Journal of the American Thyroid Association·Sabbir T RahmanSusan J Jordan
Apr 20, 2019·Clinical Endocrinology·Pierpaolo TrimboliGilles Russ

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Citations

Nov 2, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael H Weiss

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Methods Mentioned

BETA
biopsies

Software Mentioned

rms
R

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