Discriminating nicotine and non-nicotine containing e-liquids using infrared spectroscopy

Journal of Pharmaceutical and Biomedical Analysis
E DeconinckP Courselle

Abstract

In a few countries, including Belgium, nicotine-containing e-cigarettes and e-liquids are considered medicines, and therefore cannot freely be sold, but should be distributed in a pharmacy. The fact that in the neighbouring countries these products are freely available, poses a problem for custom personnel, the more the nicotine content of the products is not always labelled, especially when they are bought through internet. Therefore there is a need for easy-to-use equipment and methods to perform a first on site screening of intercepted samples, both for border control as to check label compliance of the sample. The use of attenuated total reflectance-infrared spectroscopy (ATR-IR) and near infrared spectroscopy (NIR), combined with chemometrics was evaluated for the discrimination between nicotine containing and non-nicotine containing samples. It could be concluded that both ATR-IR and NIR could be used for the discrimination when combined with the appropriate chemometric techniques. The presented techniques do not need sample preparation and result in models with a minimum of false negative samples. If a large enough training set can be established the interpretation can be fully automated, making the presented approach su...Continue Reading

References

Jun 11, 2005·Journal of Pharmaceutical and Biomedical Analysis·E DeconinckY Vander Heyden
Oct 19, 2005·Journal of Pharmaceutical and Biomedical Analysis·M J VredenbregtD de Kaste
Jun 15, 2010·Journal of Pharmaceutical and Biomedical Analysis·Pierre-Yves SacréJacques O De Beer
Sep 24, 2011·Journal of Pharmaceutical and Biomedical Analysis·E DeconinckJ De Beer
Feb 5, 2013·Journal of Chromatographic Science·Eric DeconinckJacques O De Beer
Jun 14, 2014·Journal of Pharmaceutical and Biomedical Analysis·E DeconinckJ O De Beer
Sep 1, 2014·Journal of Pharmaceutical and Biomedical Analysis·E DeconinckJ O De Beer

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