PMID: 6539703May 1, 1984Paper

Discrimination between human melanoma cell lines by fluorescence anisotropy

European Journal of Cancer & Clinical Oncology
A Weinreb, P Travo

Abstract

The fluorescence polarization of diphenylhexatriene (DPH) and trimethylammonium diphenylhexatriene (TMA-DPH) was measured when these markers were imbedded in cells of the human melanoma cell lines IGR37, IGR39, IGR3 and IGR4, as well as in cells of the mouse melanoma cell lines B16F1 and B16 F10. These measurements were performed on cell cultures which were grown on quartz plates as well as on cell suspensions. Considerable differences are found between the polarization values of the human cell lines that are related to their different origins. Differences for the plated cells are considerably greater than those for the suspensions. No differences in the polarization values were found for the two mouse melanoma lines. It is concluded that differences in lipid structural order can be found between cell types endowed with different metastasizing capabilities.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S W de LaatM Shinitzky
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R H Kramer, G L Nicolson
Dec 1, 1977·Biophysical Journal·K KinositaA Ikegami
Jan 1, 1982·British Journal of Cancer·L WeissJ C Holmes
Oct 1, 1982·The American Journal of Dermatopathology·L M Lieblich
Jul 21, 1981·Biochemistry·I YuliM Shinitzky

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Citations

Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·C GrottkeH Lage

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