Discrimination between Leave of Apocynum venetum and Its Adulterant, A. pictum Based on Antioxidant Assay and Chemical Profiles Combined with Multivariate Statistical Analysis

Antioxidants
Chi-On ChanDaniel Kam-Wah Mok

Abstract

An integrated approach including chemical and biological assessments was developed to investigate the differences between Apocynum venetum L. (AV) and its adulterant, Apocynum pictum Schrenk (AP). Ten flavonoids were tentatively identified by ultra-visible and mass spectra data. The chemical component, hyperoside, was identified as a critical parameter for discrimination of two species from the results of principal component analysis (PCA) and quantitative analysis. The anti-oxidative power of the herbal extracts were determined using 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) assay and H₂O₂-induced cell damage on LO2 cells. The results of the biological assays suggested that the chemical differences between AV and AP do lead to difference in activity and AV is demonstrated to have higher anti-oxidant activity.

References

Jun 26, 2002·Biological & Pharmaceutical Bulletin·Takako YokozawaHae Young Chung
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·Veronika ButterweckSansei Nishibe
Apr 28, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Takako Yokozawa, Takako Nakagawa
Nov 15, 2006·Journal of Ethnopharmacology·Oliver GrundmannVeronika Butterweck

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