Discrimination exposure and DNA methylation of stress-related genes in Latina mothers

Psychoneuroendocrinology
Hudson P SantosChristopher Murgatroyd

Abstract

Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory genes in Latinas. Our sample was Latina women (n = 147) with a mean age of 27.6 years who were assessed at 24-32 weeks' gestation (T1) and 4-6 weeks postpartum (T2) and reside in the U.S. Blood was collected at T1, and the Everyday Discrimination Scale (EDS) was administered at T1 and T2. DNA Methylation at candidate gene regions was determined by bisulphite pyrosequencing. Associations between EDS and DNA methylation were assessed via zero-inflated Poisson models, adjusting for covariates and multiple-test comparisons. Discrimination was negatively associated with methylation at CpG sites within the glucocorticoid receptor (NR3C1) and brain-derived neurotrophic factor (BDNF) genes that were consistent over time. In addition, discrimination was negatively associated with methylation of a CpG in the glucocorticoid binding protein (FKBP5) at T1 but not at T2. This study underscores associations between discrimination and...Continue Reading

References

Feb 10, 2006·Journal of Affective Disorders·Uriel Halbreich, Sandhya Karkun
Nov 26, 2008·Journal of Behavioral Medicine·David R Williams, Selina A Mohammed
Apr 24, 2009·Journal of Clinical Psychology·Christopher J HopwoodLeslie C Morey
Mar 2, 2010·Biological Psychiatry·Kristin BergmanThomas G O'Connor
Jan 13, 2011·Statistics in Medicine·Ian R WhiteAngela M Wood
Jul 1, 1997·Journal of Health Psychology·D R WilliamsN B Anderson
Dec 6, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Gerhard DammannReinhard H Dammann
Feb 22, 2012·Hormones and Behavior·Katharine H ZeidersMark W Roosa
Mar 28, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J P HermanB Myers
Jul 13, 2013·Frontiers in Psychology·Jean Askenasy, Joseph Lehmann
Aug 13, 2013·Epidemiology and Psychiatric Sciences·C H Liu, E Tronick
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Daniel S TyleeStephen J Glatt
Nov 14, 2013·Genes, Brain, and Behavior·A S Zannas, E B Binder
May 31, 2014·European Child & Adolescent Psychiatry·Roseriet BeijersCarolina de Weerth
Jul 25, 2014·Child Development·Sarah E RomensSeth D Pollak
Sep 17, 2014·Brain Research·Cathy Mitchelmore, Lene Gede
Nov 20, 2014·Stress : the International Journal on the Biology of Stress·Maximus Berger, Zoltán Sarnyai
Dec 9, 2014·Journal of Consulting and Clinical Psychology·Lisa S SegreMichael W O'Hara
Apr 16, 2015·Epigenetics : Official Journal of the DNA Methylation Society·E C BraithwaiteF A Champagne
Aug 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anthony S ZannasElisabeth B Binder
Oct 16, 2015·Pediatric Research·Colter MitchellDaniel A Notterman
Mar 26, 2016·World Journal of Psychiatry·Lei ZhangXian-Zhang Hu
Apr 15, 2016·American Journal of Public Health·Stephanie WallaceLaia Bécares
Nov 21, 2016·Journal of Affective Disorders·Pelin Dikmen YildizLouise Phillips
Jan 13, 2017·Obstetrics and Gynecology·Elizabeth A HowellPaul L Hebert
Aug 7, 2017·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Sandraluz Lara-CinisomoSamantha Meltzer-Brody
Nov 4, 2017·International Journal of Molecular Sciences·Tadahiro NumakawaNaoki Adachi
Dec 21, 2017·Biological Research for Nursing·Veronica Barcelona de MendozaJacquelyn Y Taylor
Dec 26, 2017·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Irene J K ParkMargarita Alegría

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Citations

Mar 13, 2020·PloS One·Rebeca Alvarado Harris, Hudson P Santos
Apr 15, 2020·Journal of Midwifery & Women's Health·Elise N EricksonNicole S Carlson
Jun 4, 2020·Translational Psychiatry·Nina AlexanderSusanne Vogel
Feb 20, 2020·International Journal of Environmental Research and Public Health·Hannah Lui Park
Aug 7, 2019·Journal of Racial and Ethnic Health Disparities·Carlye ChaneyClaudia Valeggia
Jan 15, 2021·Journal of Affective Disorders·Hudson P SantosChristopher Murgatroyd
Feb 22, 2021·Social Science & Medicine·Linnea EvansKristen Malecki
Nov 1, 2021·Physical Therapy·Dawn M Magnusson, Zachary D Rethorn
Feb 26, 2021·Biological Research for Nursing·Billy A CaceresElizabeth Corwin
Feb 6, 2022·Nature Communications·Arjun BhattacharyaHudson P Santos

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