PMID: 8955919Nov 11, 1996Paper

Discrimination of circadian phase in intact and suprachiasmatic nuclei-ablated rats

Brain Research
R E MistlbergerE G Marchant

Abstract

This study examined whether the circadian system of rats can serve as a consulted clock for discriminating time of day. Food restricted rats housed in activity wheels were trained to lever press for food in a two-lever T-maze in which the left arm was correct in a morning feeding session, and the right arm in an afternoon session (7 h interval). All six rats learned the task (discrimination ratios > chance on 85-95% of sessions) and exhibited anticipatory wheel running prior to most sessions. Performance was not disrupted by inverting the LD cycle or by omitting 1-3 sessions, indicating that learning was not dependent on light-dark cues, alternation strategies, or physiological states associated with intermeal interval. Five of six additional rats with ablations of the suprachiasmatic nucleus light-entrainable pacemaker acquired the discrimination, indicating that time-of-day cues can be provided by another circadian pacemaker (likely food-entrainable). The results provide the first clear evidence that the circadian system in a mammal can function as a consulted clock that provides discriminative time cues for cognitive processes subserving behavioral plasticity.

Citations

Feb 21, 2003·Animal Learning & Behavior·Matthew J Pizzo, Jonathon D Crystal
Apr 27, 2005·Journal of Biological Rhythms·Dipesh ChaudhuryChristopher S Colwell
Oct 9, 2007·Learning & Behavior·Matthew J Pizzo, Jonathon D Crystal
Nov 3, 2009·The European Journal of Neuroscience·Michael C Antle, Rae Silver
Jun 18, 2017·Learning & Memory·Nitin Singh ChouhanMartin Heisenberg
May 23, 2002·Animal Learning & Behavior·Jonathon D Crystal, Benjamin J Miller
Jun 7, 2012·Learning & Behavior·Scott H Deibel, Christina M Thorpe
Feb 23, 2012·PloS One·Ralph E MistlbergerMaksim Parfyonov
Oct 21, 2015·Frontiers in Neurology·Elise Facer-Childs, Roland Brandstaetter
Dec 18, 2013·Journal of Biological Rhythms·C MulderM P Gerkema
Jul 30, 2004·Learning & Behavior·Matthew J Pizzo, Jonathon D Crystal
Sep 16, 2004·Biological Reviews of the Cambridge Philosophical Society·Ralph E Mistlberger, Debra J Skene
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Norman F RubyH Craig Heller
Aug 2, 2014·Chronobiology International·Cornelis Kees MulderEddy A Van Der Zee
Dec 31, 2015·Journal of Biological Rhythms·Alexander J Lubinski, Terry L Page
Oct 20, 2018·The Journal of Experimental Biology·Byron N Van NestDarrell Moore
Aug 8, 2002·Journal of Biological Rhythms·Brandon J AragonaFriedrich K Stephan
Aug 29, 2006·Learning & Behavior·Matthew J Pizzo, Jonathon D Crystal
Dec 9, 2016·Learning & Behavior·Scott H DeibelChristina M Thorpe
Nov 3, 2009·The European Journal of Neuroscience·Ralph E Mistlberger
Oct 30, 2009·The European Journal of Neuroscience·Jonathon D Crystal
Jun 9, 2007·Learning & Behavior·Christina M Thorpe, Donald M Wilkie
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Matthew J Hartsock, Robert L Spencer
Jan 22, 2021·Neuroscience and Biobehavioral Reviews·Andrew B LehrScott H Deibel
Apr 30, 2011·Physiology & Behavior·Ralph E Mistlberger
Apr 27, 2021·Frontiers in Neuroscience·Norman F Ruby
Nov 29, 1999·Behavioural Processes·J A CarrD M Wilkie
Jul 12, 2008·BMC Neuroscience·Dipesh ChaudhuryChristopher S Colwell
Apr 24, 2015·Learning & Memory·Cornelis K MulderEddy A Van der Zee
Aug 20, 2015·Learning & Memory·Harini C Krishnan, Lisa C Lyons

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