Discrimination of multi-origin chinese herbal medicines using gas chromatography-mass spectrometry-based fatty acid profiling

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiao-Jing ZhangJian-Bo Wan

Abstract

Multi-origin Chinese herbal medicines, with herbs originating from more than one species of plants, is a common phenomenon but an important issue in Traditional Chinese Medicines (TCMs). In the present study, a gas chromatography-mass spectrometry (GC-MS)-based fatty acid profiling approach to rapidly discriminate multi-origin Chinese medicines in terms of species and medicinal parts was proposed and validated using tuberous roots (Curcumae Radix) and rhizomes (Curcumae Rhizoma and Curcumae Longae Rhizoma) derived from four Curcuma species (e.g., C. wenyujin, C. kwangsiensis, C. phaeocaulis and C. longa) as models. Both type and content of fatty acids varied among different species of either tuberous roots or rhizomes, indicating each species has its own fatty acid pattern. Orthogonal partial least squares discriminant analysis (OPLS-DA) and hierarchical clustering analysis (HCA) based on dataset of global fatty acid profiling showed that either tuberous roots or rhizomes samples could be clearly classified into four clusters according to their species. Furthermore, those tested samples could also be discriminated in terms of their medicinal parts (e.g., tuberous root and rhizome). Our findings suggest that the proposed GC-MS-b...Continue Reading

References

Aug 14, 2001·Memórias do Instituto Oswaldo Cruz·C C Araújo, L L Leon
Mar 26, 2005·BMC Biochemistry·Jing X Kang, Jingdong Wang
Jul 21, 2005·Journal of Agricultural and Food Chemistry·Quan XiaKarl W K Tsim
Oct 22, 2008·Journal of Chromatography. a·Pedro AraujoJing X Kang
Dec 15, 2012·Journal of Applied Toxicology : JAT·Yin-Hua XiongZheng-Tao Wang
Jan 23, 2013·Chemistry Central Journal·Xiao-Jing ZhangJian-Bo Wan
Apr 11, 2013·BMC Medical Genomics·Hailin Chen, Zuping Zhang

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Methods Mentioned

BETA
fatty acid profiling
electrophoresis

Software Mentioned

OPLS
SIMCA
DA
MS Search
SPSS

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