Discrimination of ovarian steroids by rats

Physiology & Behavior
B B GorzalkaL A Hanson

Abstract

Rats' ability to discriminate their hormonal states was examined by observing the effects of ovarian steroids on state-dependent learning using a drug discrimination task. A rat's entry into the correct arm (left or right) of a Y-maze terminated mild foot shock. The arm designated as correct was alternated daily, but was consistently paired with a pretrial injection of hormone or vehicle. In Experiment 1, ovariectomized rats successfully discriminated pretreatment with 4.0 or 8.0 mg/kg progesterone vs. the oil vehicle but not 2.0 or 0.5 mg/kg progesterone vs. oil, or the daily alternation schedule alone (oil vs. oil). In Experiment 2a, ovariectomized rats correctly discriminated pretreatment with progesterone (4 mg/kg) vs. oil or dihydroprogesterone (4 mg/kg) vs. oil, and the results of Experiment 2b, appear consistent with the possibility that the rats discriminated pretreatment with progesterone vs. dihydroprogesterone. In Experiment 3a, ovariectomized rats discriminated on the basis of progesterone (4.0 mg/kg) vs. oil, estrogen (6.4 micrograms/kg estradiol benzoate) vs. oil, and estrogen vs. progesterone. In Experiment 3b, the rats were adrenalectomized, and the procedure from Experiment 3a repeated. The removal of the adren...Continue Reading

References

Jul 28, 1976·Psychopharmacology·T U JärbeB G Henriksson
Apr 1, 1977·Hormones and Behavior·P Gray
Sep 1, 1976·Biology of Reproduction·R D Peppler, J J Jacobs
Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·R.P.W. HeinsbroekN.E. van De Poll
Dec 23, 1967·Nature·J StewartE Kaczender
Jun 1, 1974·Hormones and Behavior·R E Whalen
Sep 1, 1981·Behavioral and Neural Biology·D L EbnerD C Riccio
Sep 14, 1993·European Journal of Pharmacology·N A AtorR R Griffiths
Jun 1, 1965·Journal of Comparative and Physiological Psychology·S LEVINE, L E JONES

Citations

Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R De Beun
Oct 1, 2009·Future Medicinal Chemistry·C A Frye

Related Concepts

Adrenalectomy
Metazoa
Avoidance Learning
20-alpha-Dihydroprogesterone
Discrimination (Process of Differentiation)
Aerodiol
Bilateral Oophorectomy
Ovary
Progesterone, (17 alpha)-Isomer
Gonadal Steroid Hormones

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