Discrimination reversal and attentional sets in zebrafish (Danio rerio).

Behavioural Brain Research
Matthew O ParkerCaroline H Brennan

Abstract

The potential of zebrafish as a comparative model in behavioural neuroscience is currently hampered only by the lack of reliable and validated behavioural assays available to researchers. In the present experiment, we describe the performance of zebrafish in a test of attentional set formation. The fish were initially trained on a two-choice colour discrimination. Upon reaching acquisition criterion, the reinforced alternative was switched to the previously unreinforced alternative. Again, upon reaching criterion, the cues were replaced with a novel pair of colours (intra-dimensional shift) and reversed again on reaching criteria. We found that zebrafish show a steady decrease in trials-to-criteria over the four phases of the experiment, suggesting that they are forming and maintaining an attentional set, as has previously been demonstrated with mammals. Reversal learning deficits have been implicated in a variety of human psychological disorders (e.g., disorders of impulse control) and as such, we propose that performance of zebrafish in this procedure may represent a useful comparative model to complement existing rodent models.

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Nov 9, 2011·Behavioural Brain Research·Matthew O ParkerCaroline H Brennan

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Citations

Jun 4, 2013·Behavioural Processes·Kazuchika ManabeShinichi Takaku
Jul 23, 2013·Zebrafish·Matthew O ParkerCaroline H Brennan
Apr 15, 2014·Trends in Neurosciences·Adam Michael StewartAllan V Kalueff
Jan 15, 2014·Trends in Pharmacological Sciences·Allan V KalueffRobert Gerlai
May 10, 2015·Behavioural Brain Research·Tim RuhlGerhard von der Emde
Dec 10, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam Michael StewartAllan V Kalueff
Mar 19, 2014·Neuroscience and Biobehavioral Reviews·R E Blaser, D G Vira
Feb 13, 2015·Zebrafish·Jessica OliveiraAna Luchiari
Oct 30, 2014·PloS One·Michael J ProulxCaroline H Brennan
Jan 26, 2018·Proceedings. Biological Sciences·Séverine D BuechelNiclas Kolm
Oct 21, 2019·Animal Cognition·Martha M M Daniel, Vera Schluessel
Oct 12, 2019·Scientific Reports·Tamal RoyEmília P Martins
May 22, 2020·Frontiers in Molecular Biosciences·T Zhang, R T Peterson
Sep 30, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Richard J KrauzlisAnil Bollimunta
Feb 7, 2017·Experimental Neurology·Daria A MeshalkinaAllan V Kalueff

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