PMID: 2154527Jan 1, 1990

Discriminative properties of morphine that modulate associations between tastes and lithium chloride

Journal of Experimental Psychology. Animal Behavior Processes
G M MartinD van der Kooy


Wistar rats learned to withhold consumption of a target solution when morphine preceded presentation of the target solution and lithium chloride (LiCl) and to consume the same target solution when saline preceded the presentation of the solution. After this serial feature discrimination training, morphine did not block the formation of a Pavlovian association between saccharin and LiCl but did suppress consumption of familiar tap water. After Pavlovian conditioning, morphine blocked the formation of an association between saccharin and LiCl but did not suppress consumption of a familiar tap water solution. The roles of morphine and saline can be interchanged. It appears that the morphine discriminative stimulus is calling up a representation of neither the conditioned stimulus nor the unconditional stimulus alone, but rather a modified representation of some aspect of their association.


Aug 8, 1996·European Journal of Pharmacology·J H MaesJ M Vossen
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·Glenn W StevensonAnthony L Riley
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·R de BeunN E van de Poll
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A Van HestB Olivier
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S. Pournaghash, Anthony L Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S.T. Smurthwaite, Anthony L Riley
Nov 1, 1992·Behavioral and Neural Biology·Darlene M Skinner, G M Martin
Jan 1, 1992·Psychoneuroendocrinology·R de BeunN E van de Poll
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·J H Maes, J M Vossen
May 30, 2003·Learning & Memory·Dana J HowseDarlene M Skinner

Related Concepts

Association Learning
Avoidance Learning
Chloride Ion Level
Conditioned Reflex
Discrimination Learning
Dose-Response Relationship, Drug
Water Consumption
Injections, Intraperitoneal
Memory Training

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