PMID: 9160856Apr 1, 1997Paper

Discriminative stimulus effects of apomorphine and 7-OH-DPAT: a potential role for dopamine D3 receptors

Psychopharmacology
D J SangerG Perrault

Abstract

Previous studies have reported that the non-selective dopamine agonist, apomorphine, can serve effectively as a discriminative stimulus in experimental animals, and evidence has been presented that this effect is mediated by dopamine D2 receptors. More recently, it has been found that another dopamine agonist, 7-OH-DPAT, which has some selectivity for D3 receptors, also produces a discriminative cue in rats. The present study set out to make a direct comparison of the discriminative stimulus effects of these two compounds. Rats were trained to discriminate either apomorphine (0.05 mg/kg, SC) or 7-OH-DPAT (0.1 mg/kg, IP) from saline. Both discriminations were acquired but extended training was necessary. Cross generalisation occurred between the two compounds and both cues generalised to the dopamine agonists, quinpirole, quinelorane, PD 128207, and bromocriptine. When the potencies of these compounds to produce the apomorphine or 7-OH-DPAT cues were correlated with their potencies to produce D2 or D3 functional responses in vitro (mitogenesis in transfected cells-results taken from the literature) stronger correlations with D3 than with D2 responses were observed. Both the cueing and the response rate-decreasing effects of apom...Continue Reading

Citations

Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hans-Jürgen Möller
Feb 24, 1998·European Journal of Pharmacology·G B Varty, G A Higgins
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·A J ChristianL E Baker
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·B A MattinglyM Abel
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·C L Zuch, D A Cory-Slechta
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·A J Goudie, J A Smith
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·R DepoortereD J Sanger
Dec 5, 2000·Behavioural Pharmacology·J L Katz, K L Alling
Sep 2, 2015·Neurobiology of Disease·M Angela CenciHanna S Lindgren

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