PMID: 2508155Jan 1, 1989Paper

Discriminative stimulus effects of intravenous l-nicotine and nicotine analogs or metabolites in squirrel monkeys

Psychopharmacology
K TakadaJ L Katz

Abstract

Squirrel monkeys were trained to emit one response after IV administration of l-nicotine (0.4 or 0.2 mumol/kg) and a different response after IV administration of saline. After stable discriminative performances were established, subjects were tested with cumulative doses of l-nicotine (0.02-2.2 mumol/kg), d-nicotine (0.02-19.7 mumol/kg), l-nornicotine (0.2-12.0 mumol/kg), l-cotinine (56.8-567.5 mumol/kg), and dl-anabasine (0.6-19.7 mumol/kg). All of the drugs produced dose-related increases in the percentage of drug-appropriate responses emitted, from predominantly saline-appropriate responses after low doses, to predominantly drug-appropriate responses at the highest doses studied. Relative potency comparisons indicated that l-nicotine was 28 times more potent than d-nicotine, 29 times more potent than l-nornicotine, and approximately 2000 times more potent than l-cotinine. Each of the drugs also produced decreases in rates of responding, with potency order similar to that obtained for the discriminative effects. The effects of l-cotinine may be attributed to trace amounts of l-nicotine, which existed within the l-cotinine. The effects of dl-anabasine were lethal in one subject and were consequently not studied in the other s...Continue Reading

References

Aug 1, 1978·British Journal of Pharmacology·W T ChanceR M Spencer
May 1, 1988·Pharmacology, Biochemistry, and Behavior·K TakadaJ L Katz
Jul 1, 1969·The American Journal of Physiology·J A HerdL G Jones
Jan 1, 1980·Psychopharmacology·L T MeltzerL S Harris
Jun 1, 1982·Journal of Pharmacological Methods·A J BertalmioJ H Woods
Apr 1, 1963·Journal of the Experimental Analysis of Behavior·D F HAKE, N H AZRIN

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Citations

Jan 1, 1991·Psychopharmacology·J L KatzJ M Witkin
Oct 17, 2003·Archives of Pharmacal Research·Young-Yeop KohDong-Yoon Lim
Aug 10, 2006·Psychopharmacology·Shannon G MattaJeffrey M Zirger
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·T A GreenM T Bardo
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·D K HatsukamiR Bliss
Feb 20, 2016·Psychopharmacology·Rajeev I DesaiJack Bergman
Jul 30, 2014·Neuroscience and Biobehavioral Reviews·Katharine A BrennanPenelope Truman
Feb 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Amy K GoodwinMerle G Paule
Oct 2, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jenny L WileyKia J Jackson
Feb 16, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sagi ElhassanM Imad Damaj
Sep 1, 1993·Clinical Rheumatology·R MeliconiG C Astaldi Ricotti
Jan 7, 2014·The Journal of Pharmacology and Experimental Therapeutics·Rajeev I Desai, Jack Bergman
Dec 29, 2020·The Journal of Pharmacology and Experimental Therapeutics·Zheng-Ming DingXiaoying Tan

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