PMID: 2496419Jan 1, 1989Paper

Discriminative stimulus effects of nicotine in rats trained under different schedules of reinforcement

Psychopharmacology
I P Stolerman

Abstract

There have been few comparisons between different schedules of reinforcement for establishing drugs as discriminative stimuli. Fixed-ratio (FR) 10 and tandem variable-interval 1-min FR-10 schedules have been compared directly in a conventional, nicotine-saline discrimination paradigm with food reinforcement in rats. The discrimination was acquired rapidly under both schedules, with stimulus control by nicotine (0.1 mg/kg SC) being very slightly superior under the FR schedule. In 5-min extinction tests with nicotine, rats maintained under the FR schedule yielded a clear dose-response curve with a bar-selection (quantal) index; in these rats, discrimination of nicotine appeared generally poor, and dose-response curves were shallow, when the percentage of drug-appropriate responding (quantitative index) was calculated. In contrast, rats under the tandem schedule yielded clear dose-response data with both indices. In tests with (+)-amphetamine full generalization was obtained with both schedules, and with both quantitative and quantal indices. Tests of generalization to morphine were negative regardless of the training schedule or index employed. In rats under the FR-10 schedule, overall response rates declined both within and acro...Continue Reading

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Citations

Jan 1, 1995·Psychopharmacology·I P Stolerman, M J Jarvis
Aug 10, 2006·Psychopharmacology·Shannon G MattaJeffrey M Zirger
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·K F Melia, C L Ehlers
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·A N PerkinsR C MacPhail
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·M D Schechter, S M Meehan
May 20, 1997·European Journal of Pharmacology·M D Schechter
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·William L Woolverton
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·F van HaarenW R Kem
Nov 4, 1998·Drug and Alcohol Dependence·R S MansbachC S Freedland
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew I PalmatierRick A Bevins
Nov 9, 2007·Behavioural Pharmacology·Jennifer E Murray, Rick A Bevins
Oct 6, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Dec 13, 2006·Expert Opinion on Investigational Drugs·Bernard Le FollPierre Sokoloff
Mar 9, 2007·European Journal of Pharmacology·Jennifer E Murray, Rick A Bevins
Apr 3, 2016·Psychopharmacology·Kenneth A PerkinsEric C Donny
Sep 3, 2016·The American Journal of Drug and Alcohol Abuse·Stephen J Kohut
Jan 1, 1989·Journal of Psychopharmacology·I P Stolerman, H S Garcha
Jan 18, 2005·Behavioral and Cognitive Neuroscience Reviews·Rick A Bevins, Matthew I Palmatier
May 7, 2002·Behavioural Pharmacology·I P StolermanA Morley
May 1, 1996·Journal of the Experimental Analysis of Behavior·S H Snodgrass, D E McMillan
Jan 1, 1993·Journal of Psychopharmacology·D V Gauvin, F A Holloway

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